Open Access
Phase solubility techniques
T K Higuchi,A Connors +1 more
- Vol. 4, pp 212-217
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The article was published on 1965-01-01 and is currently open access. It has received 2515 citations till now. The article focuses on the topics: Phase (matter) & Solubility.read more
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Inclusion complexes of tadalafil with natural and chemically modified beta-cyclodextrins. I: preparation and in-vitro evaluation
TL;DR: The results showed the formation of true inclusion complexes between the drug and both HP-beta-CD and DM- beta-CD using the freeze-drying method at molar ratio of 1:5, which showed superior dissolution enhancement than other methods especially when combined with the Beta-CD derivatives.
Journal ArticleDOI
Synthesis and characterization of β-cyclodextrin inclusion complexes of thymol and thyme oil for antimicrobial delivery applications
TL;DR: The FD method showed to be the best encapsulation method with enhanced antimicrobial activity for both compounds, and both compounds effectively inhibited bacterial growth within the concentration range tested.
Journal ArticleDOI
Physicochemical characterization of solid dispersions of indomethacin with PEG 6000, Myrj 52, lactose, sorbitol, dextrin, and Eudragit E100.
Hadi Valizadeh,Ali Nokhodchi,Nahid Qarakhani,Parvin Zakeri-Milani,Shirzad Azarmi,Davood Hassan-Zadeh,Raimar Löbenberg +6 more
TL;DR: The results indicate that lactose, mannitol, sorbitol, and especially Myrj 52 are suitable carriers to enhance the in vitro dissolution rate of indomethacin at pH 7.2.
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Cyclodextrin solubilization of benzodiazepines: formulation of midazolam nasal spray
Thorsteinn Loftsson,Gudmundsdottir H,J. F. Sigurjónsdóttir,Hakon H. Sigurdsson,S. D. Sigfússon,Már Másson,Einar Stefánsson +6 more
TL;DR: The cyclodextrin solubilization of three benzodiazepines, i.e. alprazolam, midazolam and triazol am, was investigated, finding the ring-opening was pH-dependent and completely reversible, theRing-open forms dominating at low pH but thering-closed forms at physiologic pH.
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The effect of parenterally administered cyclodextrins on cholesterol levels in the rat.
Henderik W. Frijlink,Anko C. Eissens,Nanco R. Hefting,Klaas Poelstra,Coenraad F. Lerk,Dirk K. F. Meijer +5 more
TL;DR: The hypothesis that complex formation of endogenous cholesterol with cyclodextrins in the bloodstream leads to extraction of cholesterol from the large lipoprotein particles is tested and extravascular redistribution was directly demonstrated in histological studies of the kidneys.