Open Access
Phase solubility techniques
T K Higuchi,A Connors +1 more
- Vol. 4, pp 212-217
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The article was published on 1965-01-01 and is currently open access. It has received 2515 citations till now. The article focuses on the topics: Phase (matter) & Solubility.read more
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Enhancement of dissolution rate and bioavailability of sulfamethoxazole by complexation with β-cyclodextrin.
Nurten Özdemir,Jülide Erkin +1 more
TL;DR: The formulation, that provided delivery of active material near to the target value in six healthy volunteers and in vivo tests, clearly revealed that the bioavailability ofactive material was found to be enhanced by preparing ternary mixtures.
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Dissolution of a Mixture of Steroids in Cyclodextrin Solutions: a Model Description
TL;DR: The purpose of this study was to establish the laws of dissolution for a mixture of steroids in CD solutions and develop a simple but effective model of solubility for such steroid mixtures.
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Precipitation Complexation Method Produces Cannabidiol/β-Cyclodextrin Inclusion Complex Suitable for Sublingual Administration of Cannabidiol
TL;DR: It is demonstrated that sublingual administration of a solid CBD/beta-CD complex enhances the absorption of CBD in rabbits when compared to oral administration of ethanolic CBD.
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Controlled-release solid dispersions of Eudragit® FS 100 and poorly soluble spironolactone prepared by electrospinning and melt extrusion
Attila Balogh,Balázs Farkas,András Domokos,Attila Farkas,Balázs Démuth,Enikő Borbás,Brigitta Nagy,György Marosi,Zsombor Kristóf Nagy +8 more
TL;DR: In this article, a novel anionic metachrylate terpolymer with pH dependent solubility was processed using electrospinning for the first time and melt extrusion (EX) for controlled delivery of a poorly water-soluble model drug, spironolactone (SPIR).
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Micellisation Mechanism and Behaviour of Soluplus®⁻Furosemide Micelles: Preformulation Studies of an Oral Nanocarrier-Based System.
TL;DR: Homogeneity in the estimated micellar size and morphology was shown for monophasic micelle dispersions in lower concentrations and with a shift towards more complex structures or aggregates in higher concentrations, and the implications for oral drug delivery are discussed.