Open Access
Phase solubility techniques
T K Higuchi,A Connors +1 more
- Vol. 4, pp 212-217
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The article was published on 1965-01-01 and is currently open access. It has received 2515 citations till now. The article focuses on the topics: Phase (matter) & Solubility.read more
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Preparation and Evaluation of Amino Acid Based Salt Forms of Model Zwitterionic Drug Ciprofloxacin
TL;DR: Investigation of the zwitterionic nature of CIP and the ability of acidic and basic amino acids to form new salts with the primary aim of improving its solubility revealed that ionic and hydrophobic interactions are essential for salt formation.
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Chitosan/Sulfobutylether-β-Cyclodextrin Nanoparticles for Ibrutinib Delivery: A Potential Nanoformulation of Novel Kinase Inhibitor
TL;DR: A feasible nanocarrier is applied for ibrutinib delivery, and the potential nanoformulation maintains drug activity and shows a sustained release property, which are helpful for the formulation exploitation of tyrosine kinase inhibitors.
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Interaction of sulfadiazine with cyclodextrins in aqueous solution and solid state
TL;DR: The main objective of as mentioned in this paper was to increase the solubility of sulfadiazine by formation of inclusion complexes with β-cyclodextrin, and methyl-β-cyclodesxtrin.
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Cyclodextrin-based oral dissolving films formulation of taste-masked meloxicam.
TL;DR: In vivo studies revealed that films rapidly dissolved in the mouth and had a less bitter taste than MX, suggesting that electospun films from EtOH system may be a good candidate for fast-dissolving drug delivery systems to increase palatability of dosage forms.
Journal ArticleDOI
The influence of hydroxypropyl-β-cyclodextrin on the solubility, dissolution, cytotoxicity, and binding of riluzole with human serum albumin
TL;DR: Data analysis showed that the addition of HP-β-CD weakened the quenching and binding of RLZ with HSA but did not affect the binding site and binding force between RLZ and HSA.