Open Access
Phase solubility techniques
T K Higuchi,A Connors +1 more
- Vol. 4, pp 212-217
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The article was published on 1965-01-01 and is currently open access. It has received 2515 citations till now. The article focuses on the topics: Phase (matter) & Solubility.read more
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Mechanical grinding effect on thermodynamics and inclusion efficiency of loratadine-cyclodextrin inclusion complex formation.
TL;DR: The mechanism of inclusion complex formation for Loratadine with β-CD or LOR/HP-β-CD was proposed through the progressive reduction in LOR crystallinity, the promoted LOR amorphization, and molecular inclusion processes in the continuous energy input process of mechanical grinding.
Journal ArticleDOI
The difficulties for a photolabile drug in topical formulations: the case of diclofenac.
TL;DR: Drug photostability resulted increased significantly in comparison with that of the commercial formulations, and was found to be very fast, with a residual content of 90% only after 3.90 min under a radiant exposure of 450 Wm(-2).
Journal ArticleDOI
Construction of 6-thioguanine and 6-mercaptopurine carriers based on βcyclodextrins and gold nanoparticles
Rodrigo Sierpe,Michael Noyong,Ulrich Simon,Daniel Aguayo,Jaime Huerta,Marcelo J. Kogan,Nicolás Yutronic +6 more
TL;DR: This modification increased their solubility and improved their stability, betting by a site-specific transport due to their nanometric dimensions, among other advantages, and the in vitro permeability of the ternary systems was studied.
Journal ArticleDOI
Mucoadhesive Cyclodextrin-Modified Thiolated Poly(aspartic acid) as a Potential Ophthalmic Drug Delivery System
Mária Budai-Szűcs,Eszter L. Kiss,Barnabás Áron Szilágyi,András Szilágyi,Benjámin Gyarmati,Szilvia Berkó,Anita Kovács,Gabriella Horvát,Zoltán Aigner,Judit Soós,Erzsébet Csányi +10 more
TL;DR: Cyclodextrin-modified thiolated poly(aspartic acid) was synthesized for the incorporation of prednisolone, a lipophilic ophthalmic drug, in an aqueous in situ gellable mucoadhesive solution and provided the best release profile because the free complex can diffuse rapidly, while the bonded complex ensures a prolonged action.
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The formation of an inclusion complex of methocarbamol with hydroxypropyl-β-cyclodextrin: the effect on chemical stability, solubility and dissolution rate
TL;DR: In this article, the inclusion complex of the hydrophobic drug methocarbamol (ML) with hydroxypropyl- β -cyclodextrin (HP β CD) was prepared and characterized in the solid state and in aqueous solution.