Open Access
Phase solubility techniques
T K Higuchi,A Connors +1 more
- Vol. 4, pp 212-217
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The article was published on 1965-01-01 and is currently open access. It has received 2515 citations till now. The article focuses on the topics: Phase (matter) & Solubility.read more
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Niosomes Encapsulating Ibuprofen–Cyclodextrin Complexes: Preparation and Characterization
TL;DR: A new delivery system based on ibuprofen-β-cyclodextrin (βCd) complexation and its loading into non-ionic surfactant vesicles (NSVs) was developed to improve ib uprofen therapeutic efficacy in topical formulations.
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Physicochemical characterization and in vitro dissolution performance of ibuprofen-Captisol® (sulfobutylether sodium salt of β-CD) inclusion complexes
TL;DR: In this article, the impact of ibuprofen-captisol (sulfobutylether sodium salt of β-CD) inclusion complexes on in vitro dissolution performance was explored.
Journal ArticleDOI
Rapamycin-cyclodextrin complexation: improved solubility and dissolution rate
TL;DR: In this paper, the authors proposed to improve poor aqueous solubility and dissolution properties of anticancer drug rapamycin through formation of inclusion complexes with natural and modified cyclodextrins.
Journal ArticleDOI
Effects of an antimalarial quinazoline derivative on human erythrocytes and on cell membrane molecular models.
Yareli Rojas-Aguirre,Francisco Hernández-Luis,César Mendoza-Martínez,Carlos P. Sotomayor,Luis F. Aguilar,Fernando Villena,Ivan Castillo,David J. Hernández,Mario Suwalsky +8 more
TL;DR: Experiments are consistent with the insertion of M4/HPβCD in the outer monolayer of the human erythrocyte membrane and it can be considered a promising and novel antimalarial agent.
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Enhancement of Drug Solubility in Supramolecular and Colloidal Systems
TL;DR: It was shown that complexation may lead to improvement of the aqueous solubility of both statins by 1-2 orders of magnitude and the enhanced drug solubilities can be ascribed to the formation of CD-statin-polymer associates with supramolecular structure.