Open Access
Phase solubility techniques
T K Higuchi,A Connors +1 more
- Vol. 4, pp 212-217
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The article was published on 1965-01-01 and is currently open access. It has received 2515 citations till now. The article focuses on the topics: Phase (matter) & Solubility.read more
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Hygroscopicity, phase solubility and dissolution of various substituted sulfobutylether β-cyclodextrins (SBE) and danazol–SBE inclusion complexes
TL;DR: The dissolution of the complexes was significantly greater than that of the corresponding physical mixtures indicating that the formation of amorphous complex increased the solubility of poorly soluble danazol.
Journal ArticleDOI
Inclusion complex of usnic acid with β -cyclodextrin: characterization and nanoencapsulation into liposomes
Mariane C. B. Lira,Milena Sales Ferraz,Dáfila G. V. C. da Silva,Maria Esperanza Cortés,Karina Imaculada Rosa Teixeira,Nelly P. Caetano,Rubén D. Sinisterra,Gilles Ponchel,Nereide S. Santos-Magalhães +8 more
TL;DR: Interestingly, the encapsulation of UA:βCD into the liposomes resulted in a modulation of in vitro kinetics of release of UA, which presented a more prolonged release profile of free usnic acid compared to usnic Acid-loaded liposome.
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Physicochemical properties of the fluoroquinolone antimicrobials. III. Complexation of lomefloxacin with various metal ions and the effect of metal ion complexation on aqueous solubility
TL;DR: In this paper, the stability constants and stoichiometries of lomefloxacin were determined by measuring the change of aqueous solubility as a function of metal ion concentration.
Journal ArticleDOI
Inclusion complex of ellagic acid with β-cyclodextrin: Characterization and in vitro anti-inflammatory evaluation
Vipin D. Bulani,Pankaj S. Kothavade,Harish Kundaikar,Nitin B. Gawali,Amrita A. Chowdhury,Mariam S. Degani,Archana R. Juvekar +6 more
TL;DR: In this article, a freeze-dried inclusion complex of ellagic acid/β-cyclodextrin (EACD) was investigated both in solution and solid state by means of aqueous solubility, in-vitro dissolution, absorption, fluorescence, Fourier transform infrared spectroscopy (FTIR), powder X-ray diffractometry (XRD), scanning electron microscopy (SEM), nuclear magnetic resonance (NMR) and molecular modeling methods.
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The effects of cyclodextrins on drug absorption II. In vivo observations
TL;DR: Complex formation of diazepam and of naproxen with β-cyclodextrin results in increased aqueous solubility of the drug and the ability of mucus and bile samples to displace eomplexed drug was shown in vitro in displacement studies with phenolphthalein.