Open Access
Phase solubility techniques
T K Higuchi,A Connors +1 more
- Vol. 4, pp 212-217
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The article was published on 1965-01-01 and is currently open access. It has received 2515 citations till now. The article focuses on the topics: Phase (matter) & Solubility.read more
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Analysis of triclosan inclusion complexes with β-cyclodextrin and its water-soluble polymeric derivative
TL;DR: The results pointed out the higher affinity of EPI-βCD than βCD for the interaction with TR even in the solid state, resulting in the formation of completely amorphous products with superior dissolution properties.
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Design and Evaluation of an Osmotic Pump Tablet (OPT) for Prednisolone, a Poorly Water Soluble Drug, Using (SBE)7m-β-CD
Kazuto Okimoto,Masatoshi Miyake,Norio Ohnishi,Roger A. Rajewski,Valentine J. Stella,Tetsumi Irie,Kaneto Uekama +6 more
TL;DR: The present results confirm that (SBE)7m-β-CD can serve as both the solubilizer and the osmotic agent for OPT of Prednisolone, and modify the input rate of PDL without compromising oral bioavailability.
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Enhancement of Dissolution Rate of Valdecoxib Using Solid Dispersions with Polyethylene Glycol 4000
TL;DR: The SDs of valDecoxib with PEG 4000 exhibited enhanced dissolution rate of valdecoxib, and the rate increased with increasing concentration of Peg 4000 in SDs, which demonstrated that the reaction conditions became more favorable as the concentration ofPEG 4000 increased.
Journal ArticleDOI
Solubilization of tropicamide by hydroxypropyl-β-cyclodextrin and water-soluble polymers: in vitro/in vivo studies
Brunella Cappello,Claudia Carmignani,Maria Iervolino,M Immacolata La Rotonda,M. Fabrizio Saettone +4 more
TL;DR: Improved in vivo behaviour of the CD formulations are likely due to their physiological pH, resulting in a reduced irritant effect, although an effect of HP-beta-CD on corneal permeability cannot be dismissed a priori.
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Interaction of Omeprazole with a Methylated Derivative of β-Cyclodextrin: Phase Solubility, NMR Spectroscopy and Molecular Simulation
TL;DR: MβCD proved to be an efficient enhancer of OME solubility, thus possessing characteristics for being an useful excipient in pharmaceutical formulations of this drug.