Open Access
Phase solubility techniques
T K Higuchi,A Connors +1 more
- Vol. 4, pp 212-217
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The article was published on 1965-01-01 and is currently open access. It has received 2515 citations till now. The article focuses on the topics: Phase (matter) & Solubility.read more
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Baicalein and hydroxypropyl-γ-cyclodextrin complex in poloxamer thermal sensitive hydrogel for vaginal administration.
TL;DR: Thermosensitive hydrogel formulation of the Ba-HP-γ-CD thermosensitive Hydrogel complex appears to be a promising treatment for cervicitis.
Journal ArticleDOI
Improved Aqueous Solubility and Antihypercholesterolemic Activity of Ezetimibe on Formulating with Hydroxypropyl-β-Cyclodextrin and Hydrophilic Auxiliary Substances.
TL;DR: The use of TPGS or AA2G as ternary hydrophilic auxiliary substances improved the HPBCD solubilization and antihypercholesterolemic activity of Eze.
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Characterization of an inclusion complex of ethyl benzoate with hydroxypropyl-β-cyclodextrin
Chao Yuan,Zhifang Lu,Zhengyu Jin +2 more
TL;DR: The results showed that HPCD was a proper excipient for increasing the solubility and controlled release of ethyl benzoate.
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Amorphous ternary cyclodextrin nanocomposites of telmisartan for oral drug delivery: improved solubility and reduced pharmacokinetic variability.
Mayur Sangwai,Pradeep R. Vavia +1 more
TL;DR: An innovative particle engineering approach is explored which synergistically coalesce two principally different solubility enhancement strategies namely ternary β-cyclodextrin complexation and top-down nanonization in a unit process to improvesolubility and reduce in vivo variability in pharmacokinetic parameters of Telmisartan irrespective to physiological pH conditions.
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Host–Guest Interactions of Risperidone with Natural and Modified Cyclodextrins: Phase Solubility, Thermodynamics and Molecular Modeling Studies
TL;DR: In this article, the solubility of risperidone (Risp) in aqueous buffered cyclodextrin (CD) solution was investigated for α-, β-, γ- and HP-β-CD, and the effects of pH, ionic strength and temperature on complex stability were also explored.