Open Access
Phase solubility techniques
T K Higuchi,A Connors +1 more
- Vol. 4, pp 212-217
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The article was published on 1965-01-01 and is currently open access. It has received 2515 citations till now. The article focuses on the topics: Phase (matter) & Solubility.read more
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Modulation of drug release from hydrogels by using cyclodextrins: the case of nicardipine/β-cyclodextrin system in crosslinked polyethylenglycol
Fabiana Quaglia,Giovanna Varricchio,Agnese Miro,Maria Immacolata La Rotonda,Domenico Larobina,Giuseppe Mensitieri +5 more
TL;DR: The application of this strategy to the release of nicardipine (NIC) from swellable systems by using beta-cyclodextrin (CD) as complexant has evidenced the potential of the approach to tailor drug release.
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Sildenafil/cyclodextrin complexation: Stability constants, thermodynamics, and guest–host interactions probed by 1H NMR and molecular modeling studies
TL;DR: DSC, XRPD and 1H NMR studies proved the formation of inclusion complex in solution and the solid state and the dominant driving force for complexation is evidently van der Waals with very little electrostatic contribution.
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Microencapsulation of eugenol molecules by β-cyclodextrine as a thermal protection method of antibacterial action.
Raquel Piletti,A. M. Bugiereck,A.T. Pereira,E. Gussati,J. Dal Magro,Josiane Maria Muneron de Mello,Francieli Dalcanton,R. Z. Ternus,Cíntia Soares,Humberto Gracher Riella,Márcio Antônio Fiori +10 more
TL;DR: This work investigated the encapsulation process of eugenol molecules in β-cyclodextrine and the antibacterial properties of Eugenol-β-cyclodesxtrine (the eugenoli-βCD complex) against Escherichia coli and Staphylococcus aureus and found that the encapsulated molecules retained significant antibacterial action, which confirms the thermal protection of the eugenols molecules.
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Thermally Triggered Mucoadhesive In Situ Gel of Loratadine: β-Cyclodextrin Complex for Nasal Delivery
TL;DR: Faster drug permeation with zero-order kinetics and target flux was achieved with formulation containing drug: β-cyclodextrin complex rather than those made with free drug and was stable for over 3 months and histological examination revealed no remarkable damage to the nasal tissue.
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Dissolution properties of polyethylene glycols and polyethylene glycol-drug systems
TL;DR: In this paper, the authors investigated the influence of polyethylene glycol weight fraction on the release of hydroflumethiazide and bendrofluazide from drug-polymer solid dispersions.