Open Access
Phase solubility techniques
T K Higuchi,A Connors +1 more
- Vol. 4, pp 212-217
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The article was published on 1965-01-01 and is currently open access. It has received 2515 citations till now. The article focuses on the topics: Phase (matter) & Solubility.read more
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Journal ArticleDOI
Use of cyclodextrins in topical formulations: practical aspects.
TL;DR: The goal of using cyclodextrins to create new formulations with well-known actives, advantages, and limitations in topical formulations is presented, and possible applications in such preparations are also discussed.
Journal ArticleDOI
Drug-polymer interactions and their effect on thermoresponsive poly(N-isopropylacrylamide) drug delivery systems.
D.C. Coughlan,Owen I. Corrigan +1 more
TL;DR: Hydrophobic binding, the salting out effect and the influence of the drugs on hydrogel swelling under non-sink conditions were shown to be important effects which depended on the chemical nature of the drug present.
Journal ArticleDOI
Encapsulation of Nutraceutical Monoterpenes in β-Cyclodextrin and Modified Starch
TL;DR: Phase solubility studies showed that the inclusion complexes of thymol and geraniol with beta-CD are more soluble in water than the free molecules themselves, and the fraction of monoterpenes that can be released from their complexes with MS in aqueous media was evaluated.
Journal ArticleDOI
Quercetin/β-cyclodextrin inclusion complex embedded nanofibres: Slow release and high solubility.
TL;DR: High antioxidant activity and photostability of QU was achieved in PAA/QU/β-CD-IC-NF and 1:1 complex formation was chosen to have higher weight loading of QU.
Journal ArticleDOI
Cyclodextrins as solubilizers: formation of complex aggregates.
TL;DR: Three different techniques were applied to investigate aggregation of drug/cyclodextrin complexes, that is, drug permeation through semi-permeable membranes, determination of changes in the value of activity coefficients ofdrug/cyclODExtrin complex solutions and transmission electron microscopy (TEM).