Open Access
Phase solubility techniques
T K Higuchi,A Connors +1 more
- Vol. 4, pp 212-217
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The article was published on 1965-01-01 and is currently open access. It has received 2515 citations till now. The article focuses on the topics: Phase (matter) & Solubility.read more
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Journal ArticleDOI
Enhancement of solubility of albendazole by complexation with β-cyclodextrin
Cristiane Moriwaki,Glauciane de Lara Costa,C. N. Ferracini,F. F. De Moraes,Gisella Maria Zanin,Edgardo Alfonso Gómez Pineda,Graciette Matioli +6 more
TL;DR: In this paper, a complexation with β-cyclodextrin (β-CD) using aqueous and acetic acid solutions as ABZ solubilizer was studied, showing that high β-CD molar ratios hold ABZ in solution by complexation enhanced by the acetate anion.
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Preparation and characterization of etoricoxib-β-cyclodextrin complexes prepared by the kneading method
TL;DR: The dissolution of etoricoxib was notably increased as compared to pure drug as well as its physical mixture, and the results indicate partial interaction of the drug with β-CD in the physical mixture and complete interaction in the kneaded complex.
Journal ArticleDOI
Development of parenteral formulation for a novel angiogenesis inhibitor, CKD-732 through complexation with hydroxypropyl-β-cyclodextrin
TL;DR: It is demonstrated that the CKD-732/HP-beta-CyD complex is an attractive formulation for use in the parenteral delivery of CKD the angiogenesis inhibitor.
Journal ArticleDOI
Complexation of carbendazim with hydroxypropyl-β-cyclodextrin to improve solubility and fungicidal activity.
TL;DR: The obtained inclusion complex MBC·HPβCD was found to significantly improve the water solubility of MBC and the biological activity indicated that the complex displayed the better fungicidal activity than MBC.
Journal ArticleDOI
A mucoadhesive, cyclodextrin-based vaginal cream formulation of itraconazole
Francois Marc Karel Jozef,Eric Carolus Leonarda Snoeckx,Peter Putteman,Fons Wouters,Eddy De Proost,Urbain Alfons Lieven Delaet,Jef Peeters,Marcus E. Brewster +7 more
TL;DR: In this paper, a novel itraconazoleamide formulation intended for vaginal use based on hydroxypropyl-β-cyclodextrin (HPβCD), a functional excipient that increases drug solubility and generates a mucoadhesive system in the presence of other ingredients.