Open Access
Phase solubility techniques
T K Higuchi,A Connors +1 more
- Vol. 4, pp 212-217
About:
The article was published on 1965-01-01 and is currently open access. It has received 2515 citations till now. The article focuses on the topics: Phase (matter) & Solubility.read more
Citations
More filters
Journal ArticleDOI
Inclusion complexation of amide-typed local anaesthetics with β-cyclodextrin and its derivatives. II. Evaluation of affinity constants and in vitro transfer rate constants
TL;DR: In this article, the solubility increase of the amide-type (LAs) in the presence of CDs was quantified for each LA-CD system by determination of the stability constant, from the slope of the phase-solubility diagram.
Journal ArticleDOI
Phase solubility and FTIR-ATR studies of idebenone/sulfobutyl ether β-cyclodextrin inclusion complex
Carmela Cannavà,Vincenzo Crupi,M. Guardo,Domenico Majolino,Rosanna Stancanelli,Silvana Tommasini,Cinzia Anna Ventura,Valentina Venuti +7 more
TL;DR: In this paper, the favorable accessibility of sulfobutyl ether β-cyclodextrin (SBE-β-CD) for the complexation with idebenone (IDE) has been probed, as a function of temperature, by phase solubility study, and, in solid state, by FTIR-ATR technique.
Journal ArticleDOI
Development of Imiquimod-Loaded Mucoadhesive Films for Oral Dysplasia
TL;DR: A noninvasive and local approach with the potential to treat precancerous lesions may be achieved by this described mucoadhesive drug delivery system.
Journal ArticleDOI
Comparative study of ibuproxam complexation with amorphous β-cyclodextrin derivatives in solution and in the solid state
TL;DR: A clear reduction of complexing ability was observed, indicative of some steric interferences to drug inclusion due to the presence of substituents, but this negative effect was not reflected in the dissolution behaviour of their solid binary systems, probably thanks to the greater amorphizing properties shown by betaCd derivatives.
Journal ArticleDOI
Solubility Properties of Racemic Praziquantel and Its Enantiomers
TL;DR: The solubility and thermodynamic properties of the optical isomers of the anti-schistosomal drug, praziquantel (PZQ) are characterized to compare these properties to those of the racemic product used in commercial preparations.