Open Access
Phase solubility techniques
T K Higuchi,A Connors +1 more
- Vol. 4, pp 212-217
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The article was published on 1965-01-01 and is currently open access. It has received 2515 citations till now. The article focuses on the topics: Phase (matter) & Solubility.read more
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Cyclodextrin inclusion complexes of antimycotics intended to act in the oral cavity--drug supersaturation, toxicity on TR146 cells and release from a delivery system.
TL;DR: The dissolution rate, the toxicity and the release from chewing gum of miconazole and econazole cyclodextrin products and complexes and physical mixtures did not give supersaturation and were not as toxic as the above-mentioned compounds.
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Physiochemical Characterization and Release Rate Studies of SolidDispersions of Ketoconazole with Pluronic F127 and PVP K-30
TL;DR: The results obtained showed that the rate of dissolution of Ketoconazole was considerably improved when formulated in solid dispersions with PVP K-30 and Pluronic F-127 as compared with pure drug and physical mixtures.
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Poly propyl ether imine (PETIM) dendrimer: A novel non-toxic dendrimer for sustained drug delivery
Subheet Jain,Amanpreet Kaur,Richa Puri,Puneet Utreja,Anubhuti Jain,Mahesh Bhide,Rakesh Ratnam,Vinay Singh,Andanagouda Sharanappagouda Patil,N. Jayaraman,Gaurav Kaushik,Subodh Yadav,Krishan Lal Khanduja +12 more
TL;DR: It is demonstrated that G3-COOH PETIM dendrimer can be used as a safe and efficient vehicle for sustained drug delivery.
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Physicochemical characterization and in vivo properties of Zolpidem in solid dispersions with polyethylene glycol 4000 and 6000.
Giuseppe Trapani,Massimo Franco,Andrea Latrofa,Maria Rosaria Pantaleo,Maria Rosaria Provenzano,Enrico Sanna,Elisabetta Maciocco,Gaetano Liso +7 more
TL;DR: These formulations of Zolpidem showed almost two- to three-fold longer ataxic induction times suggesting that, in the presence of PEG, the intestinal membrane permeability is probably the rate-limiting factor of the absorption process.
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Diclofenac-β-cyclodextrin binary systems: Physicochemical characterization and in vitro dissolution and diffusion studies
Maria Letizia Manca,Marco Zaru,Guido Ennas,Donatella Valenti,Chiara Sinico,Giuseppe Loy,Anna Maria Fadda +6 more
TL;DR: The physicochemical characterization of diclofenac-β-cyclodextrin binary systems was performed both in solution and solid state and revealed that the drug dissolution rate was improved by the presence of CDs and the highest and promptest release was obtained with the freeze-dried binary system.