Open Access
Phase solubility techniques
T K Higuchi,A Connors +1 more
- Vol. 4, pp 212-217
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The article was published on 1965-01-01 and is currently open access. It has received 2515 citations till now. The article focuses on the topics: Phase (matter) & Solubility.read more
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Functionalization of acrylic hydrogels with α-, β- or γ-cyclodextrin modulates protein adsorption and antifungal delivery
Jose-Fernando Rosa dos Santos,Juan-Jose Torres-Labandeira,Nele Matthijs,Tom Coenye,Angel Concheiro,Carmen Alvarez-Lorenzo +5 more
TL;DR: Poly(hydroxyethyl methacrylate) hydrogels were functionalized with pendant alpha-, beta- and gamma-cyclodextrins to improve the biocompatibility and increasing the ability to host drug molecules.
Journal ArticleDOI
Inclusion complexes of cannabidiol with β-cyclodextrin and its derivative: Physicochemical properties, water solubility, and antioxidant activity
Hang Li,Chang Senlin,Chang Tanran,Ying You,Xiaodong Wang,Wang Liwei,Xiaofan Yuan,Ming-Hui Tan,Wang Peidong,Peng-Wei Xu,Wei-Bo Gao,Qingsheng Zhao,Bing Zhao +12 more
TL;DR: In this paper, the physicochemical properties, water solubility, and dissolution rate of the inclusion complexes of CBD with β-cyclodextrin (β-CD) and 2, 6-di-O-methyl-β-cyclodextrin (DM-β -CD), and to determine the influence of complexation on the antioxidant activity of CBD.
Journal ArticleDOI
Dissolution enhancement of gliclazide by preparation of inclusion complexes with β-cyclodextrin
TL;DR: In this article, the authors have emphasized on improving the solubility and dissolution rate of gliclazide by forming inclusion complex with β-cyclodextrin, which is an oral hypoglycemic agent used in the treatment of noninsulin-dependent diabetes mellitus.
Patent
Formulations containing clopidogrel and sulfoalkyl ether cyclodextrin and methods of use
Gerold L. Mosher,Rebecca L. Wedel,Karen T. Johnson,Stephen G. Machatha,Jane A. Cowee,Daniel J. Cushing +5 more
TL;DR: In this article, the sulfoalkyl ether cyclodextrin (SAE-CD) is used to aid in dissolution and stabilization of clopidogrel in aqueous media.
Journal ArticleDOI
In-vitro and in-vivo cytotoxicity and efficacy evaluation of novel glycyl-glycine and alanyl-alanine conjugates of chitosan and trimethyl chitosan nano-particles as carriers for oral insulin delivery.
Nersi Jafary Omid,Nika Bahari Javan,Ahmad Reza Dehpour,Alireza Partoazar,Morteza Rafiee Tehrani,Farid Abedin Dorkoosh +5 more
TL;DR: It seems that glycyl-glycine and alanyl-alanine conjugate nanoparticles of trimethyl chitosan have met the aim of this research work and have been able to orally deliver insulin with more than one mechanism in animal model.