Open Access
Phase solubility techniques
T K Higuchi,A Connors +1 more
- Vol. 4, pp 212-217
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The article was published on 1965-01-01 and is currently open access. It has received 2515 citations till now. The article focuses on the topics: Phase (matter) & Solubility.read more
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Inclusion complex of a new propiconazole derivative with β-cyclodextrin: NMR, ESI-MS and preliminary pharmacological studies.
Narcisa Marangoci,Mihai Mares,Mihaela Silion,Adrian Fifere,Cristian Varganici,Alina Nicolescu,Calin Deleanu,Adina Coroaba,Mariana Pinteala,Bogdan C. Simionescu +9 more
TL;DR: High antifungal activities for NO3PCZ and its inclusion complex, compared with its PCZ analog and the acute toxicity of the complex is smaller than the pure or modified drug, recommending the inclusion complex as future promising therapeutic agents.
Journal ArticleDOI
6-O-α-(4-O-α-D-glucuronyl)-D-glucosyl-β-cyclodextrin: solubilizing ability and some cellular effects
Sumitra Tavornvipas,Fumitoshi Hirayama,Hidetoshi Arima,Kaneto Uekama,Toshihiro Ishiguro,Masahide Oka,Kenichi Hamayasu,Hitoshi Hashimoto +7 more
TL;DR: In this paper, physicochemical and biopharmaceutical properties of a new branched cyclodextrin, 6-O-alpha-(4-O -alpha-D-glucuronyl)-D-Glucosyl-beta-cyclodesxtrin (GUG-β-CyD), were investigated by spectroscopic and solubility methods.
Journal ArticleDOI
Sulfobutylether-β-cyclodextrin/chitosan nano- and microparticles and their physicochemical characteristics.
TL;DR: The ability of the NPs to encapsulate HC decreased with increasing CS concentration during preparation of theNPs even though the SBEβCD content ofThe NPs increased with increasingCS concentration; the ionic crosslinking provides better encapsulation at low initial SBE βCD and CS concentrations.
Journal ArticleDOI
The Role of l -arginine in Inclusion Complexes of Omeprazole with Cyclodextrins
Ana Figueiras,J. M. G. Sarraguça,J. M. G. Sarraguça,Alberto A. C. C. Pais,Rui A. Carvalho,J. Francisco Veiga +5 more
TL;DR: L-arginine (ARG) significantly increases the drug solubility and complex stability, in comparison to inclusion complexes formed in its absence, and contributes to a larger stability of OME when free in aqueous solution.
Journal ArticleDOI
Improvement of oral and rectal bioavailabilities of carmofur by methylated β-cyclodextrin complexations
TL;DR: Inclusion complex formation of carmofur (1-hexyl carbamoyl-5-fluorouracil; HCFU) with β-CyD, heptakis(2,6-di-O-methyl)-β-cyclodextrin (DM-β-Cyd) and heptonakis (2,3, 6-tri-O -methyl) β-cyclodioxyl-methyl (TM-βCyD) were assessed by solubility method, thermal analysis and powder X-ray diffractometry