Open Access
Phase solubility techniques
T K Higuchi,A Connors +1 more
- Vol. 4, pp 212-217
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The article was published on 1965-01-01 and is currently open access. It has received 2515 citations till now. The article focuses on the topics: Phase (matter) & Solubility.read more
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Novel cyclodextrin-based film formulation intended for buccal delivery of atenolol
TL;DR: Although incorporation of atenolol in the form of an inclusion complex into hydrophilic films may be an appropriate strategy to prepare a suitable formulation for buccal drug delivery, other parameters that influenced the drug release rate were associated with the structure of the polymer used in the formulation, swelling characteristics of the films, and the interaction between atenoliol and hydrophobic polymers that was demonstrated by FTIR analysis.
Journal ArticleDOI
RSM-CCD optimized microwave assisted synthesis of chitosan and sodium alginate based nanocomposite containing inclusion complexes of β-cyclodextrin and amlodipine besylate for sustained drug delivery systems
Khushbu,Rajeev Jindal +1 more
TL;DR: In this article, a nanocomposite was synthesized by incorporating the graphene oxide (GO) in the polymer network of chitosan (CH) and sodium alginate (ALG) under microwave conditions.
Journal ArticleDOI
Physico-chemical characterization of disoxaril-dimethyl- β-cyclodextrin inclusion complex and in vitro permeation studies
Cinzia Anna Ventura,Ignazio Giannone,Teresa Musumeci,Rosario Pignatello,Lorella Ragni,Carla Landolfi,Claudio Milanese,Donatella Paolino,Giovanni Puglisi +8 more
TL;DR: In vivo studies on rabbits evidenced that WIN 51711 is well tolerated, having no observable effect on the nasal mucosa following repeatedAdministration, increasing its water solubility and stability.
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Antibacterial and antioxidant properties of hesperidin:β-cyclodextrin complexes obtained by different techniques
Andreia Corciova,Constantin Ciobanu,Antonia Poiată,Cornelia Mircea,Alina Nicolescu,Mioara Drobota,Cristian-Dragos Varganici,Tudor Pinteala,Narcisa Marangoci +8 more
Abstract: The purpose of this study was to investigate the influence of β-cyclodextrin on aqueous solubility of hesperidin. The inclusion complexes were prepared by different methods (kneading, co-evaporation and lyophilization) and were tested for their antimicrobial and antioxidant activities. Solubility diagrams were drawn at four temperatures (20, 25, 37 and 40 °C) and the corresponding stability constants were calculated. The solubility diagrams obtained were of AL type and the stoichiometric ratio was 1:1. Moreover, the thermodynamic parameters of the complexation reaction were calculated: Gibbs free energy change, free energy change, enthalpy change and entropy change. The results showed that the complexation reaction is more effective with the increase in temperature and in cyclodextrin concentration. The inclusion process is endothermic and spontaneous and the interactions between hesperidin and β-cyclodextrin are hydrophobic. UV–Vis, FTIR, 1HNMR, methods provided valuable information about complex formation. Antibacterial activity was investigated by the agar diffusion method, against Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922 and Candida
albicans ATCC 10231. The results revealed that all the prepared compounds display a higher antibacterial activity compared to hesperidin. Also, the inclusion compounds presented an improved antioxidant activity, demonstrated by the determination of inhibition of lipoxygenase activity, DPPH radical scavenging activity and determination of reducing capacity. In vitro dissolution tests demonstrated that the inclusion compounds have an improved dissolution, compared to free hesperidin. The enhancement in the solubility, antibacterial and antioxidant activities depend on the method of preparation.