Open Access
Phase solubility techniques
T K Higuchi,A Connors +1 more
- Vol. 4, pp 212-217
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The article was published on 1965-01-01 and is currently open access. It has received 2515 citations till now. The article focuses on the topics: Phase (matter) & Solubility.read more
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Statistically designed enzymatic hydrolysis of an icariin/β-cyclodextrin inclusion complex optimized for production of icaritin
TL;DR: In this article, an icariin/β-cyclodextrin inclusion complex was used to generate icaritin, which increased the solubility by 17-fold.
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Experimental and mesoscale computational dynamics studies of the relationship between solubility and release of quercetin from PEG solid dispersions.
TL;DR: It is suggested that the increase in release of quercetin in a PEG solid dispersion would only be beneficial if it were administered at the site of absorption, e.g. rectal administration, to ensure absorption prior to phase separation.
Journal ArticleDOI
Solubilization and dissolution of tamoxifen‐hydroxybutenyl cyclodextrin complexes
Charles Michael Buchanan,Norma Lindsey Buchanan,Kevin J. Edgar,Juanelle Little Lambert,Jessica Dee Posey-Dowty,Michael G. Ramsey,Michael F. Wempe +6 more
TL;DR: These dissolution studies demonstrated that enhanced solubilization of tamoxifen with HBenBCD was effective across a wide variety of formulation options.
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Comparison of the complexation between methylprednisolone and different cyclodextrins in solution by 1H-NMR and molecular modeling studies.
Thao Do Thi,Koen Nauwelaerts,Matheus Froeyen,Luc Baudemprez,Michiel Van Speybroeck,Patrick Augustijns,Pieter Annaert,Johan A. Martens,Jan Van Humbeeck,Guy Van den Mooter +9 more
TL;DR: Two possibilities of complex formation are proposed: (1) methylprednisolone enters HP-beta-CD from the wider rim by its D and C ring, and (2) the A and B ring of methyl Prednisol one enters deeper in to the CD cavity so that a part of the A ring of steroidal structure is outside of the cavity.