Open Access
Phase solubility techniques
T K Higuchi,A Connors +1 more
- Vol. 4, pp 212-217
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The article was published on 1965-01-01 and is currently open access. It has received 2515 citations till now. The article focuses on the topics: Phase (matter) & Solubility.read more
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Acyclic cucurbit[n]uril-type molecular containers: influence of aromatic walls on their function as solubilizing excipients for insoluble drugs.
Ben Zhang,Lyle Isaacs +1 more
TL;DR: Containers 1a and 1b are broadly applicable and can be used to formulate a wider variety of insoluble drugs than was previously possible with cyclodextrin technology.
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Characterization, dissolution and bioavailability in rats of ibuprofen-β-cyclodextrin complex system
DahNan D. Chow,Adel H. Karara +1 more
TL;DR: In this article, phase solubility studies revealed a 12-fold increase in the Solubility of ibuprofen and the formation of an insoluble microcrystalline complex in the presence of high concentration of β-cyclodextrin (β-CD).
Journal ArticleDOI
New "drug-in cyclodextrin-in deformable liposomes" formulations to improve the therapeutic efficacy of local anaesthetics.
TL;DR: Double-loaded liposomes, exploiting the favourable effects of drug-CD complexation, allowed a significant (P<0.05) enhancement of intensity and duration of anaesthetic effect with respect to those single-loaded.
Journal ArticleDOI
Phase solubility and inclusion complex of itraconazole with β‐cyclodextrin using supercritical carbon dioxide
TL;DR: Results showed that beta-cyclodextrin significantly improved solubility of itraconazole in aqueous solutions and higher inclusion yields were obtained in the SC CO(2) method compared to physical mixing and coprecipitation methods.
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Quercetin/β-Cyclodextrin Solid Complexes Prepared in Aqueous Solution Followed by Spray-drying or by Physical Mixture
TL;DR: The present study was designed to investigate the influence of operating conditions on the complexation of quercetin with β-cyclodextrin using a 23 factorial design and found the highest aqueous solubility of querbetin was reached under the conditions 37°C/24 h/6 mM of quERCetin.