Open Access
Phase solubility techniques
T K Higuchi,A Connors +1 more
- Vol. 4, pp 212-217
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The article was published on 1965-01-01 and is currently open access. It has received 2515 citations till now. The article focuses on the topics: Phase (matter) & Solubility.read more
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Synthesis and characterization of the inclusion complex between repaglinide and sulfobutylether-β-cyclodextrin (Captisol ® )
TL;DR: In this article, an inclusion complex between repaglinide and a cyclodextrin derivative, 7-sulfobutylether-β-cyclodesxtrin (Captisol®), was synthesized and characterized taking into account its possible benefits regarding the solubility.
Journal ArticleDOI
Pharmacodynamic and pharmacokinetic investigation of cyclodextrin-mediated asenapine maleate in situ nasal gel for improved bioavailability.
TL;DR: Thermo-responsive in situ nasal gel containing asenapine maleate-hydroxyl propyl β cyclodextrin inclusion complex (AM-HPβCD) was prepared and bioavailability in rats by nasal route was increased by 2.5 fold.
Lyophilized gliclazidepoloxamer solid dispersions for enhancement of in vitro dissolution and invivo bioavailability
TL;DR: Results demonstrate that the use of a suitable hydrophilic carrier like PXM to formulate SDs by the lyophillisation technique can rapidly accelerate the solubi lity and in vitro dissolution of a lipophilic drug like GLC.
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Alginate-Based Hydrogel Containing Minoxidil/Hydroxypropyl-β-Cyclodextrin Inclusion Complex for Topical Alopecia Treatment
Angela Lopedota,Nunzio Denora,Valentino Laquintana,Annalisa Cutrignelli,Antonio Lopalco,Domenico Tricarico,Fatima Maqoud,Angela Curci,Maria Mastrodonato,Flavia la Forgia,Sergio Fontana,Massimo Franco +11 more
TL;DR: Rheological and in vitro release studies performed on the formulation loaded with MXD 3.5% w/w proved that the inclusion complex increased the viscosity of the hydrogel modulating the release of the free drug, suggesting that these completely aqueous MXD delivery systems can be proposed as alternative formulations to commercial solutions.
Journal ArticleDOI
Formulation and evaluation of fixed-dose combination of bilayer gastroretentive matrix tablet containing atorvastatin as fast-release and atenolol as sustained-release
TL;DR: It can be concluded that the bilayer tablets of atorvastatin and atenolol can be successfully employed for the treatment of hypertension and hypercholesterolemia together through oral administration of single tablet.