Open Access
Phase solubility techniques
T K Higuchi,A Connors +1 more
- Vol. 4, pp 212-217
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The article was published on 1965-01-01 and is currently open access. It has received 2515 citations till now. The article focuses on the topics: Phase (matter) & Solubility.read more
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Complex formation of sericoside with hydrophilic cyclodextrins: improvement of solubility and skin penetration in topical emulsion based formulations.
TL;DR: The main objective of this study was to devise novel methods for improving the solubility of the anti-inflammatory triterpenoid sericoside, the main component of Terminalia sericea extract, thus enabling its incorporation into topical formulations.
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Preparation and characterization of soluble branched ionic β-cyclodextrins and their inclusion complexes with triclosan.
F. Gómez-Galván,Leyre Pérez-Álvarez,Janire Matas,Arturo Álvarez-Bautista,Joana Poejo,Catarina M.M. Duarte,Leire Ruiz-Rubio,Jose Luis Vila-Vilela,Luis Manuel León +8 more
TL;DR: Water solubility of both ionic derivatives was similar (400 mg/mL) at neutral and basic pHs and remarkably higher than that of their neutral homologues and Cytotoxicity of ionic bβCDs was evaluated on Human colon carcinoma Caco-2 cells.
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Nanoaggregation of inclusion complexes of glibenclamide with cyclodextrins
TL;DR: A 150-fold enhancement of drug solubility has been achieved using β-cyclodextrin derivatives, which has proven to be an interesting tool to improve the oral administration of glibenclamide in accordance with dosage bulk and dose/solubility ratio requirements.
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Solubility of sinapic acid in various (Carbitol + water) systems: computational modeling and solution thermodynamics
TL;DR: In this paper, the solubility and solution thermodynamic properties of a bioactive nutraceutical sinapic acid (SA) in different 2-ethoxyethoxy)ethanol (Carbitol®) + water mixtures were investigated.
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Synthesis and Evaluation of Mesoporous Carbon/Lipid Bilayer Nanocomposites for Improved Oral Delivery of the Poorly Water-Soluble Drug, Nimodipine
TL;DR: The data reported herein suggest that the MCLN matrix is a promising carrier for controlling the drug release rate and improving the oral absorption of poorly water-soluble drugs.