Open Access
Phase solubility techniques
T K Higuchi,A Connors +1 more
- Vol. 4, pp 212-217
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The article was published on 1965-01-01 and is currently open access. It has received 2515 citations till now. The article focuses on the topics: Phase (matter) & Solubility.read more
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Studies on trimethoprim:hydroxypropyl-β-cyclodextrin: aggregate and complex formation.
TL;DR: The use of differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA) showed that the thermal stability of the drug is enhanced in the presence of HP-β-CD, and demonstrated that trimethoprim solubility was significantly increased upon complexation with HP- β-CD.
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Ternary system of dihydroartemisinin with hydroxypropyl-β-cyclodextrin and lecithin: simultaneous enhancement of drug solubility and stability in aqueous solutions.
Dan Wang,Haiyan Li,Jingkai Gu,Tao Guo,Shuo Yang,Shuo Yang,Zhen Guo,Xueju Zhang,Weifeng Zhu,Jiwen Zhang,Jiwen Zhang +10 more
TL;DR: The ternary system prepared in this study, with simultaneous enhancement of D HA solubility and stability in aqueous solutions, might have an important pharmaceutical potential in the development of a better oral formulation of DHA.
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The effect of pH and triethanolamine on sulfisoxazole complexation with hydroxypropyl-β-cyclodextrin
TL;DR: In this paper, a novel complexation of sulfisoxazole with hydroxypropyl-β-cyclodextrin (HP-β)-CD was studied, and two systems were used: binary complexes prepared with HPβ-CD and multicomponent system (HP and the basic compound triethanolamine (TEA).
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2-hydroxypropyl-β-cyclodextrin in topical carbonic anhydrase inhibitor formulations
Thorsteinn Loftsson,Hafrún Friðriksdóttir,S. Thórisdóttir,Einar Stefánsson,Anna M. Sigurðardóttir,Örn Guðmundsson,Thór Sigthórsson +6 more
TL;DR: Results indicate that HPβCD increases the ocular bioavailability of acetazolamide molecules in solution and increasing their availability at the surface of the corneal barrier without penetrating the barrier itself.
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Inclusion complex of chrysin with sulfobutyl ether-β-cyclodextrin (Captisol®): Preparation, characterization, molecular modelling and in vitro anticancer activity
TL;DR: In this article, the authors demonstrate the impact of sulfobutyl ether-β-cyclodextrin (SBEβ-CD, Captisol ® ) complexation on the solubility, dissolution and pH stability of the poorly soluble polyphenol chrysin (CHR) by freeze-drying technique.