Journal ArticleDOI
Prevalence and characteristics of age-related macular degeneration in the Japanese population: the Nagahama study.
Isao Nakata,Kenji Yamashiro,Hideo Nakanishi,Yumiko Akagi-Kurashige,Masahiro Miyake,Akitaka Tsujikawa,Fumihiko Matsuda,Nagahisa Yoshimura +7 more
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TLDR
The prevalence of early AMD among adult Japanese persons was similar to the rates in white populations, whereas that in Japanese people aged ≥70 years was relatively lower.Citations
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New loci and coding variants confer risk for age-related macular degeneration in East Asians
Ching-Yu Cheng,Kenji Yamashiro,Li Jia Chen,Jeeyun Ahn,Lulin Huang,Lvzhen Huang,Chui Ming Gemmy Cheung,Masahiro Miyake,Peter Cackett,Ian Yeo,Augustinus Laude,Ranjana Mathur,Junxiong Pang,Kar Seng Sim,Adrian Koh,Peng Chen,Shu Yen Lee,Doric Wong,Choi Mun Chan,Boon Kwang Loh,Yaoyao Sun,Sonia Davila,Isao Nakata,Hideo Nakanishi,Yumiko Akagi-Kurashige,Norimoto Gotoh,Akitaka Tsujikawa,Fumihiko Matsuda,Keisuke Mori,Shin Yoneya,Yoichi Sakurada,Hiroyuki Iijima,Tomohiro Iida,Shigeru Honda,Timothy Y Y Lai,Pancy O. S. Tam,Haoyu Chen,Shibo Tang,Xiaoyan Ding,Feng Wen,Fang Lu,Xiongze Zhang,Yi Shi,Peiquan Zhao,Bowen Zhao,Jinghong Sang,Bo Gong,Rajkumar Dorajoo,Jian-Min Yuan,Woon-Puay Koh,Rob M. van Dam,Yechiel Friedlander,Ying Lin,Martin L. Hibberd,Jia Nee Foo,Ningli Wang,Chang Hua Wong,Gavin Tan,Sang Jun Park,Mayuri Bhargava,Lingam Gopal,Thet Naing,Jiemin Liao,Peng Guan Ong,Paul Mitchell,Peng Zhou,Xuefeng Xie,Jinlong Liang,Junpu Mei,Xin Jin,Seang-Mei Saw,Mineo Ozaki,Takanori Mizoguchi,Yasuo Kurimoto,Se Joon Woo,Hum Chung,Hyeong Gon Yu,Joo Young Shin,Dong Ho Park,In Taek Kim,Woohyok Chang,Min Sagong,Sang Joon Lee,Hyun Woong Kim,Ji Eun Lee,Yi Li,Jianjun Liu,Yik Ying Teo,Chew-Kiat Heng,Tock Han Lim,Suk-Kyun Yang,Kyuyoung Song,Eranga N. Vithana,Tin Aung,Jin Xin Bei,Yi Xin Zeng,E. Shyong Tai,Xiaoxin Li,Zhenglin Yang,Kyu Hyung Park,Chi Pui Pang,Nagahisa Yoshimura,Tien Yin Wong,Chiea Chuen Khor +103 more
TL;DR: The findings suggest that some of the genetic loci conferring AMD susceptibility in East Asians are shared with Europeans, yet AMD in East Asia may also have a distinct genetic signature.
Journal ArticleDOI
Age-Related Macular Degeneration Preferred Practice Pattern®.
Christina J. Flaxel,Ron A. Adelman,Steven T. Bailey,Amani A. Fawzi,Jennifer I. Lim,G. Atma Vemulakonda,Gui-Shuang Ying +6 more
TL;DR: This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record.
Journal ArticleDOI
Pachychoroid neovasculopathy and age-related macular degeneration.
Masahiro Miyake,Sotaro Ooto,Kenji Yamashiro,Ayako Takahashi,Munemitsu Yoshikawa,Yumiko Akagi-Kurashige,Naoko Ueda-Arakawa,Akio Oishi,Hideo Nakanishi,Hiroshi Tamura,Akitaka Tsujikawa,Akitaka Tsujikawa,Nagahisa Yoshimura +12 more
TL;DR: Results implicate that the etiologies of the two conditions must be different, and it will be necessary to distinguish these two conditions in future studies.
Journal ArticleDOI
Meta-analysis of gene–environment-wide association scans accounting for education level identifies additional loci for refractive error
Qiao Fan,Qiao Fan,Virginie J. M. Verhoeven,Robert Wojciechowski,Robert Wojciechowski,Veluchamy A. Barathi,Pirro G. Hysi,Jeremy A. Guggenheim,René Höhn,René Höhn,Veronique Vitart,Anthony P Khawaja,Kenji Yamashiro,S. Mohsen Hosseini,Terho Lehtimäki,Yi Lu,Toomas Haller,Jing Xie,Cécile Delcourt,Mario Pirastu,Juho Wedenoja,Puya Gharahkhani,Cristina Venturini,Cristina Venturini,Masahiro Miyake,Alex W. Hewitt,Alex W. Hewitt,Xiaobo Guo,Johanna Mazur,Jenifer E. Huffman,Katie M Williams,Ozren Polasek,Harry Campbell,Igor Rudan,Zoran Vatavuk,James F. Wilson,Peter K. Joshi,George McMahon,Beate St Pourcain,David M. Evans,David M. Evans,Claire L. Simpson,Tae Hwi Schwantes-An,Robert P. Igo,Alireza Mirshahi,Audrey Cougnard-Gregoire,Céline Bellenguez,Maria Blettner,Olli T. Raitakari,Mika Kähönen,Ilkka Seppälä,Tanja Zeller,Thomas Meitinger,Janina S. Ried,Christian Gieger,Laura Portas,Elisabeth M. van Leeuwen,Najaf Amin,André G. Uitterlinden,Fernando Rivadeneira,Albert Hofman,Johannes R. Vingerling,Ya Xing Wang,Xu Wang,Eileen Tai-Hui Boh,M. Kamran Ikram,M. Kamran Ikram,Charumathi Sabanayagam,Charumathi Sabanayagam,Preeti Gupta,Vincent Tan,Lei Zhou,Candice E H Ho,Wan’E. Lim,Roger W. Beuerman,Rosalynn Grace Siantar,Rosalynn Grace Siantar,E. Shyong Tai,Eranga N. Vithana,Evelin Mihailov,Chiea Chuen Khor,Chiea Chuen Khor,Chiea Chuen Khor,Caroline Hayward,Robert Luben,Paul J. Foster,Barbara E.K. Klein,Ronald Klein,Hoi Suen Wong,Paul Mitchell,Andres Metspalu,Tin Aung,Tin Aung,Terri L. Young,Mingguang He,Olavi Pärssinen,Cornelia M. van Duijn,Jie Jin Wang,Cathy Williams,Jost B. Jonas,Jost B. Jonas,Yik Ying Teo,David A. Mackey,David A. Mackey,Konrad Oexle,Nagahisa Yoshimura,Andrew D. Paterson,Norbert Pfeiffer,Tien Yin Wong,Paul N. Baird,Dwight Stambolian,Joan E. Bailey Wilson,Ching-Yu Cheng,Ching-Yu Cheng,Christopher J Hammond,Caroline C W Klaver,Seang-Mei Saw,Jugnoo S Rahi,Jugnoo S Rahi,Jean-François Korobelnik,Jean-François Korobelnik,John P. Kemp,Nicholas J. Timpson,George Davey Smith,Jamie E Craig,Kathryn P. Burdon,Rhys Fogarty,Sudha K. Iyengar,Emily Y. Chew,Sarayut Janmahasatian,Nicholas G. Martin,Stuart MacGregor,Liang Xu,Maria Schache,Vinay Nangia,Songhomitra Panda-Jonas,Alan F. Wright,Jeremy Fondran,Jonathan H. Lass,Sheng Feng,Jing Hua Zhao,Kay-Tee Khaw,Nicholas J. Wareham,Taina Rantanen,Jaakko Kaprio,Jaakko Kaprio,Chi Pui Pang,Li Jia Chen,Pancy O. S. Tam,Vishal Jhanji,Alvin L. Young,Angela Döring,Leslie J. Raffel,Mary Frances Cotch,Xiaohui Li,Shea Ping Yip,Maurice Yap,Ginevra Biino,Simona Vaccargiu,Maurizio Fossarello,Brian W Fleck,Seyhan Yazar,Seyhan Yazar,Jan Willem L Tideman,Milly S. Tedja,Margaret M. DeAngelis,Margaux A. Morrison,Lindsay A. Farrer,Xiangtian Zhou,Wei Chen,Nobuhisa Mizuki,Akira Meguro,Kari-Matti Mäkelä +172 more
TL;DR: Six novel loci (FAM150B-ACP1, LINC00340, FBN1, DIS3L-MAP2K1, ARID2-SNAT1 and SLC14A2) associated with refractive error are identified and represent an important advance in understanding how gene and environment interactions contribute to the heterogeneity of myopia.
Journal ArticleDOI
Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia
Masahiro Miyake,Kenji Yamashiro,Yasuharu Tabara,Kenji Suda,Satoshi Morooka,Hideo Nakanishi,Chiea Chuen Khor,Peng Chen,Fan Qiao,Isao Nakata,Yumiko Akagi-Kurashige,Norimoto Gotoh,Akitaka Tsujikawa,Akira Meguro,Sentaro Kusuhara,Ozen Polasek,Caroline Hayward,Alan F. Wright,Harry Campbell,Andrea J. Richardson,Maria Schache,Masaki Takeuchi,Masaki Takeuchi,David A. Mackey,David A. Mackey,Alex W. Hewitt,Gabriel Cuellar,Yi Shi,Luling Huang,Zhenglin Yang,Zhenglin Yang,Kim Hung Leung,Patrick Y. P. Kao,Maurice Yap,Shea Ping Yip,Muka Moriyama,Kyoko Ohno-Matsui,Nobuhisa Mizuki,Stuart MacGregor,Veronique Vitart,Tin Aung,Seang-Mei Saw,E-Shyong Tai,Tien Yin Wong,Tien Yin Wong,Ching-Yu Cheng,Paul N. Baird,Ryo Yamada,Fumihiko Matsuda,Nagahisa Yoshimura +49 more
TL;DR: A two-stage genome-wide association study for three myopia-related traits in 9,804 Japanese individuals was extended with trans-ethnic replication in 2,674 Chinese and 2,690 Caucasian individuals, suggesting its possible role in the development of myopia.
References
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Journal ArticleDOI
Ranibizumab and bevacizumab for neovascular age-related macular degeneration.
Daniel F. Martin,Maureen G. Maguire,Gui-Shuang Ying,Juan E. Grunwald,Stuart L. Fine,Glenn J. Jaffe +5 more
TL;DR: Ranibizumab given as needed with monthly evaluation had effects on vision that were equivalent to those of ranibizuab administered monthly, although the comparison between bevacizumAB as needed and monthly bevicizumabs was inconclusive.
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Prevalence of age-related maculopathy. The Beaver Dam Eye Study.
TL;DR: In this article, the relationship between retinal drusen, retinal pigmentary abnormalities, and macular degeneration to age and sex was studied in 4926 people between the ages of 43 and 86 years who participated in the Beaver Dam Eye Study.
Journal ArticleDOI
The Beaver Dam Eye Study. Retinopathy in adults with newly discovered and previously diagnosed diabetes mellitus.
TL;DR: The prevalence of diabetic retinopathy was examined in people with newly discovered noninsulin-dependent diabetes mellitus (NIDDM) (n = 50) and in those with previously diagnosed diabetes.
Journal ArticleDOI
The Five-year Incidence and Progression of Age-related Maculopathy: The Beaver Dam Eye Study
TL;DR: It is demonstrated that the presence of soft drusen and pigmentary abnormalities significantly increases the risk for the development of geographic atrophy and exudative macular degeneration in people 75 years of age or older, and in women compared with men that age.
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