Journal ArticleDOI
Rate of release of medicaments from ointment bases containing drugs in suspension
TLDR
An equation relating the rate of release of solid drugs suspended in ointment bases into perfect sinks is derived and the final expression is found to be surprisingly simple and convenient.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1961-10-01. It has received 2031 citations till now. The article focuses on the topics: Ointment Bases.read more
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Gastroretentive hydrodynamically balanced systems of ofloxacin: In vitro evaluation
TL;DR: The drug release pattern of these HBS capsules containing ofloxacin followed the Higuchi model with the anomalous transport mechanism, and the in vitro drug release was dependent on HPMC K4M, PVP K 30, and liquid paraffin content.
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Theoretical analysis of the release of slowly dissolving drugs from spherical matrix systems.
TL;DR: A new analytical short-time approximation for drug release from spherical matrix systems complements the formulas existing in the literature, since it provides a superior description of the release of slowly dissolving drugs.
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Drug delivery systems 5A. Oral drug delivery.
TL;DR: The oral and other therapeutic systems in human use have validated the concept that controlled continuous drug release can minimize the daily dose of a drug required to maintain the required therapeutic effect, while minimizing unwanted pharmacological effects.
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Improved vaginal retention and enhanced antifungal activity of miconazole microsponges gel: Formulation development and in vivo therapeutic efficacy in rats
TL;DR: In vivo, MCZ microsponges vaginal gel was more effective than the market product in eradicating Candida infection in rats, which was supported by the histopathological findings.
Journal ArticleDOI
Development of sericin/alginate particles by ionic gelation technique for the controlled release of diclofenac sodium
Jacyara Moreira Martins Vidart,Thiago Lopes da Silva,Paulo Cesar Pires Rosa,M.G.A. Vieira,Meuris Gurgel Carlos da Silva +4 more
TL;DR: In this paper, ten particle compositions of sericin, alginate, and diclofenac were evaluated and the drug incorporation was confirmed by scanning electron microscopy, Fourier Transform Infrared Spectroscopy, and X-ray diffraction analysis.