Journal ArticleDOI
Rate of release of medicaments from ointment bases containing drugs in suspension
TLDR
An equation relating the rate of release of solid drugs suspended in ointment bases into perfect sinks is derived and the final expression is found to be surprisingly simple and convenient.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1961-10-01. It has received 2031 citations till now. The article focuses on the topics: Ointment Bases.read more
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Flow-directed loading of block copolymer micelles with hydrophobic probes in a gas-liquid microreactor
TL;DR: On-chip loading shows a significant improvement over the off-chip process where shear-induced formation of smaller micelles enables increased encapsulation of probe, and off- chip release kinetics can be controlled via flow rate.
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Vehicle Effects in Percutaneous Absorption: In Vitro Study of Influence of Solvent Power and Microscopic Viscosity of Vehicle on Benzocaine Release from Suspension Hydrogels
TL;DR: The release through silicone rubber membranes of benzocaine suspended in carbomer hydrogels containing different concentrations of low molecular weight polysols was studied to establish general principles and procedures for control of the effects on percutaneous absorption caused by changes in drug solubility and/or diffusivity in the vehicle.
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A theoretical model for transdermal drug delivery from emulsions and its dependence upon formulation.
TL;DR: A proposed model of transdermal drug delivery from an emulsion-type vehicle that addresses the vehicle heterogeneity and incorporates the prediction of drug transport parameters as function of the vehicle composition provides a sound physicochemical basis to support the development of new formulations and the planning of experiments.
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Diffusion of drugs from hydrogels and liposomes as drug carriers
Rada Pjanović,Nevenka Bošković-Vragolović,Jelena Veljković‐Giga,Radmila Garic-Grulovic,Srdjan Pejanović,Branko Bugarski +5 more
TL;DR: Calculated diffusion coefficients and resistances demonstrate that liposomes, as drug carriers, significantly affect diffusion rates, and could be used whenever diffusion-controlled drug release is required.
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Release of drugs from ointment bases II: in vitro release of benzocaine from suspension‐type aqueous gels
TL;DR: The particle size of released benzocaine did not influence the release pattern, thus confirming release in the present conditions to be diffusion rather than dissolution controlled, and the solubility and diffusion coefficient were in agreement with literature data.