Journal ArticleDOI
Rate of release of medicaments from ointment bases containing drugs in suspension
TLDR
An equation relating the rate of release of solid drugs suspended in ointment bases into perfect sinks is derived and the final expression is found to be surprisingly simple and convenient.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1961-10-01. It has received 2031 citations till now. The article focuses on the topics: Ointment Bases.read more
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Halloysite nanotubes as particulate emulsifier: Preparation of biocompatible drug‐carrying PLGA microspheres based on pickering emulsion
TL;DR: In this article, a Halloysite nanotubes (HNTs)-coated micrometer-sized poly(lactic-coglycolic acid) (PLGA) microparticles were fabricated via a combined system of "Pickering-type" emulsion route and solvent volatilization method in the absence of any molecular surfactants.
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Optimization and In vivo Pharmacokinetic Study of a Novel Controlled Release Venlafaxine Hydrochloride Three-Layer Tablet
TL;DR: It could be concluded that a promising once-daily extended-release three-layer tablet of the highly water soluble drug, VenHCl, was successfully designed and satisfied the bioequivalence criteria.
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Some mechanical property considerations of reconstituted collagen for drug release supports.
W G Bradley,G L Wilkes +1 more
TL;DR: Reconstituted collagen, having been shown previously to be biodegradable and to have low immunologic activity, has been further evaluated here as a vehicle for drug delivery.
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Preparation and characterization of genipin-cross-linked silk fibroin/chitosan sustained-release microspheres
TL;DR: The SF–CS composite microsphere exhibited higher sustained release than did the pure CS microspheres, and thus these composite micro Spheres might function as a superior drug carrier.
Journal ArticleDOI
Sink conditions do not guarantee the absence of saturation effects
TL;DR: This articles aims at giving a brief overview on the underlying physico-chemical phenomena involved in drug dissolution and drug release, clarifying some key terms, and presenting several examples of dosage forms in which drug saturation effects within the system are of importance, even when providing sink conditions in the surrounding bulk fluid.