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Journal ArticleDOI

Rate of release of medicaments from ointment bases containing drugs in suspension

Takeru Higuchi
- 01 Oct 1961 - 
- Vol. 50, Iss: 10, pp 874-875
TLDR
An equation relating the rate of release of solid drugs suspended in ointment bases into perfect sinks is derived and the final expression is found to be surprisingly simple and convenient.
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This article is published in Journal of Pharmaceutical Sciences.The article was published on 1961-10-01. It has received 2031 citations till now. The article focuses on the topics: Ointment Bases.

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Dosage form with salicylic acid attached to a polyanhydride polymer dispersed in an Eudragit matrix

TL;DR: In this paper, a new method was presented for preparing dosage forms capable of delivering drug at a controlled rate, which are prepared by dispersing in a polymeric matrix such as Eudragit, a polymer to which the drug is attached.
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Development of Theophylline Microbeads Using Pregelatinized Breadfruit Starch (Artocarpus altilis) as a Novel Co-polymer for Controlled Release.

TL;DR: Breadfruit starch was suitable as a copolymer for the controlled delivery of theophylline in microbeads which could serve as a substitute to synthetic polymers in drug delivery.
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Recent Advances in Various Stimuli-Responsive Hydrogels: From Synthetic Designs to Emerging Healthcare Applications

TL;DR: In this article , the development of the broad interest in the synthesis of unique stimuli-responsive materials and their various healthcare applications, the stimuliresponsive hydrogels have drawn major importance.
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Formulation and physicochemical characterization of chitosan/Acyclovir co-crystals

TL;DR: The thermograms showed a decrease in the melting enthalpy of acyclovir indicating a disorder in the crystalline content whereas IR spectroscopy studies revealed an interaction between acy Clovir and chitosan.
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Influence of formulation, receptor fluid, and occlusion, on in vitro drug release from topical dosage forms, using an automated flow-through diffusion cell.

TL;DR: The flow-through diffusion cell proposed in the present study allows an accurate comparison of drug release characteristics from prototype topical formulations and therefore represents a valuable tool for formulation research or quality control process.
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