Journal ArticleDOI
Rate of release of medicaments from ointment bases containing drugs in suspension
TLDR
An equation relating the rate of release of solid drugs suspended in ointment bases into perfect sinks is derived and the final expression is found to be surprisingly simple and convenient.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1961-10-01. It has received 2031 citations till now. The article focuses on the topics: Ointment Bases.read more
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Effect of the size of biodegradable microparticles on drug release: experiment and theory.
TL;DR: Investigation of the effect of the size of biodegradable microparticles (monolithic dispersions) on the release rate of an incorporated drug in a quantitative way revealed that the degradation behavior of the matrix forming polymer was not significantly affected by the sizes of the devices and that autocatalytic effects do not seem to play a major role.
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Diffusional release of a solute from a polymeric matrix — approximate analytical solutions
TL;DR: In this article, a refined integral method has been successfully applied to moving boundary problems encountered in the diffusional release of a solute from a polymeric matrix, and the release kinetics has been analyzed for both erodible and non-erodible matrices with perfect sink and constant, finite external volume conditions.
Controlled release: mechanisms and release.
Richard W. Baker,H.K. Lonsdale +1 more
TL;DR: In this paper, a control-release system of drug administration is discussed with an explanation of how the controlled release of agents according to zero-order of 1st-order kinetics arises from membrane-moderated devices and the application of diffusion laws.
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Protein release kinetics for core–shell hybrid nanoparticles based on the layer-by-layer assembly of alginate and chitosan on liposomes
TL;DR: The L-b-L deposition technique succeeded in building a spherical, monodisperse and stable hybrid nanoparticulate protein delivery system that features an extended shelf life and can be loaded immediately prior to administration, thus preventing any loss of the protein.
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Invited review polymeric delivery systems for controlled drug release
TL;DR: This review focuses primarily on the applications of polymeric systems, and their release mechanisms, which include diffusive, chemical, swelling, and magnetic control of drug release from polymers.