Journal ArticleDOI
Rate of release of medicaments from ointment bases containing drugs in suspension
TLDR
An equation relating the rate of release of solid drugs suspended in ointment bases into perfect sinks is derived and the final expression is found to be surprisingly simple and convenient.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1961-10-01. It has received 2031 citations till now. The article focuses on the topics: Ointment Bases.read more
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Swelling, erosion and drug release characteristics of Sodium Diclofenac from heterogeneous matrix tablets
TL;DR: In this article, the effect of combination lipophilic (Acryl-EZE ® ) and hydrophilic (HPMC) polymers on the release of Sodium Diclofenac (DS) from a tablet was investigated.
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Rapid photo-crosslinking of fumaric acid monoethyl ester-functionalized poly(trimethylene carbonate) oligomers for drug delivery applications
TL;DR: Photo-crosslinkable, fumaric acid monoethyl ester-functionalized poly(trimethylene carbonate) oligomers were synthesized and copolymerized with N-vinyl pyrrolidone (NVP) and vinyl acetate (VAc) to form biodegradable polymer networks.
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Theoretical analysis of inward hemispheric release above and below drug solubility
TL;DR: A detailed analysis of inward diffusional drug release from devices with hemispheric and related geometries is presented, showing that the previously used zero-order release assumption is not quite correct, even at later times, and this affects parameter estimation procedures.
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Optimization of acyclovir oral tablets based on gastroretention technology: factorial design analysis and physicochemical characterization studies.
TL;DR: It is concluded that a combination of hydroxypropylmethylcellulose 4000, Compritol 888, and sodium bicarbonate can be used to increase the gastric residence time of the dosage form up to 12 h and seem to be a promising gastroretentive drug delivery system.
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Modeling of dispersed-drug release from two-dimensional matrix tablets.
TL;DR: A mathematical model was developed and analytical solutions were obtained for dispersed-drug release from two-dimensional matrix tablets in a perfect sink to describe kinetics of solute release from matrices with isotropic or anisotropic properties.