Journal ArticleDOI
Rate of release of medicaments from ointment bases containing drugs in suspension
TLDR
An equation relating the rate of release of solid drugs suspended in ointment bases into perfect sinks is derived and the final expression is found to be surprisingly simple and convenient.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1961-10-01. It has received 2031 citations till now. The article focuses on the topics: Ointment Bases.read more
Citations
More filters
Journal ArticleDOI
Wax-based sustained release matrix pellets prepared by a novel freeze pelletization technique II. In vitro drug release studies and release mechanisms.
TL;DR: Pellets capable of providing a variety of release profiles for different drugs can be prepared using this freeze pelletization technique by suitably modifying the pellet forming matrix compositions.
Journal ArticleDOI
Diffusion model for drug release from suspensions II: release to a perfect sink.
F. Tom Lindstrom,James W. Ayres +1 more
TL;DR: The predicted mass of drug released versus time curves using this model are in agreement with some reported experimental data but differ from predictions using the classical model for semisolid suspensions, in relation to the drug dissolution rate and diffusion rate in the vehicle.
Journal ArticleDOI
Release of Highly Water-Soluble Medicinal Compounds from Inert, Heterogeneous Matrixes. I: Physical Mixture
TL;DR: The release from a matrix compressed from a physical mixture of hydrogenated castor oil and ephedrine hydrochloride or procaine hydrochlorides has been investigated and the effects on release of the concentration of medicinal compound, particle size, agitation of dissolution medium, and porosity and tortuosity of the matrix are presented.
Journal ArticleDOI
Modelling of drug release kinetics from a laminated device having an erodible drug reservoir
TL;DR: Results indicate that the constant rate of release characteristic of erodible devices is not sacrificed with the addition of the secondary membrane; moreover, the membrane provides additional controllable parameters at the disposal of the device designer.