Journal ArticleDOI
Rate of release of medicaments from ointment bases containing drugs in suspension
TLDR
An equation relating the rate of release of solid drugs suspended in ointment bases into perfect sinks is derived and the final expression is found to be surprisingly simple and convenient.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1961-10-01. It has received 2031 citations till now. The article focuses on the topics: Ointment Bases.read more
Citations
More filters
Journal ArticleDOI
Development of a mechanism and an accurate and simple mathematical model for the description of drug release: Application to a relevant example of acetazolamide-controlled release from a bio-inspired elastin-based hydrogel.
TL;DR: The in vitro release model proposed herein provides a valuable predictive tool for ensuring product performance and batch-to-batch reproducibility, thus paving the way for the development of further pharmaceutical devices.
Journal ArticleDOI
Controlled release of argatroban from PLA film—Effect of hydroxylesters as additives on enhancement of drug release
TL;DR: In this paper, a drug eluting stent that prevents vein restenosis was developed by using hydroxyl tartrate (DET), diethyl malate (DEM), and triethyl citrate (TEC).
Journal ArticleDOI
Development and application of a nanocomposite derived from crosslinked HPMC and Au nanoparticles for colon targeted drug delivery
Abstract: Herein, we report a novel route for the synthesis of a poly(acrylamide) (PAAm) crosslinked hydroxypropyl methyl cellulose/Au nanocomposite where chemically crosslinked HPMC (c-HPMC) works as a reducing agent. At first, the crosslinked polymer was developed by grafting PAAm chains onto the HPMC backbone using ethylene glycol dimethacrylate (EGDMA) crosslinker and potassium persulfate (K2S2O8) initiator. Afterwards, AuNPs have been incorporated in situ on the surface of the crosslinked hydrogel, where the hydrogel itself reduces the tetrachloroauric acid (HAuCl4) in the reaction medium to form the nanocomposite. Different grades of nanocomposites (c-HPMC/Au) have been synthesized by altering the reaction parameters and the best one was optimized with the help of UV-visible spectroscopy. The nanocomposites synthesized, have been characterized by FTIR spectroscopy, 13C NMR spectroscopy, XRD studies, FESEM/EDAX/elemental mapping analyses, HR-TEM analysis and TGA analysis. HR-TEM analysis reveals the uniform distribution of spherical AuNPs on the surface of c-HPMC. Rheological characteristics disclose that the nanocomposite demonstrates higher gel strength than that of the crosslinked polymer, mainly because of the enhanced interactions between the organic matrix and inorganic fillers. The pH responsive behaviour of crosslinked hydrogel/composites has been confirmed by measuring the equilibrium swelling ratio in various buffer solutions (pH 1.2 and 7.4) at 37 °C. Biodegradability of the hydrogel/nanocomposite has been verified using hen egg lysozyme. The synthesized nanocomposite also demonstrates non-cytotoxic behaviour towards human mesenchymal stem cells (hMSCs). The in vitro drug release profiles indicate that both ornidazole and 5-amino salicylic acid (5-ASA) are released from the nanocomposite matrix in a controlled fashion. This confirms that the c-HPMC/Au nanocomposite is likely be an excellent alternative for the controlled release of colonic drugs. The release kinetics and mechanism of ornidazole and 5-ASA from the nanocomposite material has been explained using various linear and non-linear mathematical models.
Journal ArticleDOI
Reviewing the use of ethylcellulose, methylcellulose and hypromellose in microencapsulation. Part 3: Applications for microcapsules.
True L. Rogers,Dave Wallick +1 more
TL;DR: The need for a three-part review reflects the extensive amount of literature identified concerning these three encapsulating polymers and it is hoped that formulators can use Part 3 to understand the various end-use applications of microcapsules made from these encapsulatingpolymers.
Journal ArticleDOI
Biocompatibility and drug release behavior of curcumin conjugated gold nanoparticles from aminosilane-functionalized electrospun poly(N-vinyl-2-pyrrolidone) fibers
TL;DR: Curcumin (CUR) has a wide spectrum of biological and pharmacological activities, yet problems of its bioavailability remained a major challenge in preclinical studies, so the design of the delivery systems with CUR as a model drug featuring dual release process to provide the optimal drug pharmacokinetics in the therapeutic region has been actively pursued.