Journal ArticleDOI
Rate of release of medicaments from ointment bases containing drugs in suspension
TLDR
An equation relating the rate of release of solid drugs suspended in ointment bases into perfect sinks is derived and the final expression is found to be surprisingly simple and convenient.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1961-10-01. It has received 2031 citations till now. The article focuses on the topics: Ointment Bases.read more
Citations
More filters
Journal ArticleDOI
Theoretical investigation of drug release from planar matrix systems: effects of a finite dissolution rate
TL;DR: The new analytical short-time approximation of the drug release complements the formulas existing in the literature, since it provides a superior description of the release of slowly dissolving drugs.
Journal ArticleDOI
Synthesis and characterization of hydroxyapatite-ciprofloxacin delivery systems by precipitation and spray drying technique.
TL;DR: This method provides a unique way of producing various shapes and drug loads of HAP microspheres that can be easily manufactured on a commercial scale.
Journal ArticleDOI
5-Fluorouracil-loaded multilayered films for drug controlled releasing stent application: Drug release, microstructure, and ex vivo permeation behaviors
TL;DR: With the virtue of releasing drug in a unidirectional and controlled manner, the multilayered films provide an attractive mode to produce polymeric drug delivery stents for localized treatment of stenosis or occlusion.
Journal ArticleDOI
Hybrid films from blends of chitosan and egg phosphatidylcholine for localized delivery of paclitaxel.
TL;DR: FTIR analysis of chitosan-ePC films revealed that their high stability may be attributed to interactions present between these two biomaterials, and in vitro evaluation of the cytotoxicity and protein adsorption properties of the films provided a preliminary indication of their biocompatibility.
Journal ArticleDOI
Drug release studies on an oil-water emulsion based on a eutectic mixture of lidocaine and prilocaine as the dispersed phase.
TL;DR: The in vitro drug release properties of a topical anesthetic formulation known to be effective on intact skin, based on a 1:1 eutectic mixture of lidocaine and prilocaine emulsified in water, were investigated with a poly(dimethylsiloxane) membrane partition model.