Journal ArticleDOI
Rate of release of medicaments from ointment bases containing drugs in suspension
TLDR
An equation relating the rate of release of solid drugs suspended in ointment bases into perfect sinks is derived and the final expression is found to be surprisingly simple and convenient.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1961-10-01. It has received 2031 citations till now. The article focuses on the topics: Ointment Bases.read more
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Enhanced drug encapsulation and extended release profiles of calcium–alginate nanoparticles by using tannic acid as a bridging cross-linking agent
TL;DR: The incorporation of tannic acid into Ca–alginate NPs led to more than four folds increase in drug encapsulation efficiency, and reduced burst drug release from 44% to around 10% within the first 30 min, suggesting the possibility of improving the properties of Ca-alginated NPs by incorporating cross-linking aid agents under mild conditions.
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Finite element analysis of the release of slowly dissolving drugs from cylindrical matrix systems
TL;DR: Important discrepancies exist between the numerical and analytical results, which are attributed to the simplifying assumption made in the PSS analysis that the region containing solid drug remains cylindrical in shape throughout the release process.
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Development and characterization of Eudragit based mucoadhesive buccal patches of salbutamol sulfate
TL;DR: Stability studies indicated that there was no change in the chemical and physical characteristics during the test period and data of in vitro release from patches were fitted to different kinetic models such as Higuchi and Korsmeyer-Peppas models to explain the release profile.
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Effect of water content on transparency, swelling, lidocaine diffusion in p-HEMA gels
Derya Gulsen,Anuj Chauhan +1 more
TL;DR: In this paper, the authors investigated the dependencies of transparency, swelling and lidocaine diffusion on the water content in the polymerizing mixture in p-HEMA gels and showed that the diffusivity of the lidocane is independent of the aqueous drug concentration for WCIPM.
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Directly compressed mini matrix tablets containing ibuprofen: preparation and evaluation of sustained release.
TL;DR: In identical quantities, EC produced a greater sustaining release effect than HPMC and the contribution of diffusion was predominant in the ibuprofen release process.