Journal ArticleDOI
Rate of release of medicaments from ointment bases containing drugs in suspension
TLDR
An equation relating the rate of release of solid drugs suspended in ointment bases into perfect sinks is derived and the final expression is found to be surprisingly simple and convenient.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1961-10-01. It has received 2031 citations till now. The article focuses on the topics: Ointment Bases.read more
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Development and evaluation of ointment and cream vehicles for a new topical steroid, fluclorolone acetonide
TL;DR: Enhanced drug release and superior vasoconstrictor activity were demonstrated by fluclorolone acetonide when prepared in vehicles in which it was entirely solubilized, demonstrating the usefulness of in vitro release studies in predicting vehicle efficacy.
Journal ArticleDOI
Finite element analysis of slow drug release through deformed coating film: effects of morphology and average thickness of coating film
Bing Hung Chen,D.J Lee +1 more
TL;DR: The effects of the morphology and the average thickness of the deformed coating films on the slow diffusional release characteristics analyzed numerically under the constraints of the constant volume of the drug matrices and the coating films are presented.
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Influence of Formulation Factors on Tablet Formulations with Liquid Permeation Enhancer Using Factorial Design
TL;DR: Polymer type displayed the highest and statistically significant effect on compressibility index, tablet hardness, and dissolution rate, and statistical design helped in better understanding the effect of formulation factors on tablet characteristics important for designing formulations with desired characteristics.
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A new diffusion cell — an automated method for measuring the pharmaceutical availability of topical dosage forms
TL;DR: A cyclic system, incorporating a novel diffusion cell, that can measure the pharmaceutical availability of an active principal in; topical dosage form is presented and proposed as an aid to pre-formulation and as a quality control tool.
Journal ArticleDOI
Effect of cogrinding time on the release of pentoxifylline from waxy matrix tablets.
Makoto Otsuka,Yoshihisa Matsuda +1 more
TL;DR: X-ray powder diffraction analysis of the ground drug-wax indicated that particle size could be reduced by grinding without polymorphic transformation, and scanning electron microphotographs of the coground product after dissolution tests suggested that mechanochemical energy had been used to cover the drug particles.