Journal ArticleDOI
Rate of release of medicaments from ointment bases containing drugs in suspension
TLDR
An equation relating the rate of release of solid drugs suspended in ointment bases into perfect sinks is derived and the final expression is found to be surprisingly simple and convenient.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1961-10-01. It has received 2031 citations till now. The article focuses on the topics: Ointment Bases.read more
Citations
More filters
Journal ArticleDOI
Functionalized silica nanoparticles as a carrier for Betamethasone Sodium Phosphate: Drug release study and statistical optimization of drug loading by response surface method.
TL;DR: Cell culture and cytotoxicity assays revealed the synthesized product doesn't have any cytot toxicity against human bladder cell line 5637, and the produced drug-loaded nanostructures can be applied via different routes, such as implantation and topical or oral administration.
Journal ArticleDOI
Enhancement of skin permeation of ketotifen by supersaturation generated by amorphous form of the drug
TL;DR: The results suggest that the increase in skin permeation of ketotifen from PSA matrix was due to the supersaturation generated by amorphous form, and that the amorphously form was stable during the application period.
Journal ArticleDOI
Enhanced antibacterial activity of Egyptian local insects' chitosan-based nanoparticles loaded with ciprofloxacin-HCl
TL;DR: Chitosan-based nanoparticles (CSNPs) showed countless interest as polymeric drug delivery system (DDS) with its improved bioavailability, and stability when compared with traditional DDS, and characterized using particle size distribution, zeta potential, and drug entrapment efficiency.
Journal ArticleDOI
A Novel Approach for Analyzing the Dissolution Mechanism of Solid Dispersions
TL;DR: The chemical-potential-gradient model combined with PC-SAFT can be used to analyze the dissolution mechanism of solid dispersions and to describe and predict the dissolution profiles of API as function of stirring speed, temperature and pH value of the medium.
Journal ArticleDOI
The interplay of phase inversion and membrane formation in the drug release characteristics of a membrane-based delivery system
Decheng Ma,Anthony J. McHugh +1 more
TL;DR: Naproxen was shown to inhibit the locking-in of the phase invertion structure by lowering the glass transition temperature of the naproxen/CA membrane, and the burst effect for high DL films was avoided for membranes with the honeycomb structure.