Journal ArticleDOI
Rate of release of medicaments from ointment bases containing drugs in suspension
TLDR
An equation relating the rate of release of solid drugs suspended in ointment bases into perfect sinks is derived and the final expression is found to be surprisingly simple and convenient.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1961-10-01. It has received 2031 citations till now. The article focuses on the topics: Ointment Bases.read more
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Monte Carlo simulations and fractional kinetics considerations for the Higuchi equation.
TL;DR: The application of the Higuchi equation to different geometries is discussed and Monte Carlo simulations to verify the validity of Higuchi law in one and two dimensions, as well as the derivation of theHiguchi equation under alternative boundary conditions making use of fractional calculus are presented.
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In vitro release from oil injectables for intra-articular administration: Importance of interfacial area, diffusivity and partitioning.
TL;DR: It was shown that the drug release rate was dependent on the drug diffusivity in the oil and the degree of agitation generated in theOil vehicle, and the partitioning of the drug between the oil vehicle and the release media was found to influence the release rate.
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Dry emulsion ― a sustained release form: modelling of drug transfers in liquids
TL;DR: In this article, a galenic form made of a dry emulsion was described and tested by considering the drug release in synthetic liquids, and the theoretical results for the kinetics of drug release were in good agreement with the corresponding experimental ones.
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From Heuristic to Mathematical Modeling of Drugs Dissolution Profiles: Application of Artificial Neural Networks and Genetic Programming
Aleksander Mendyk,Sinan Güres,Renata Jachowicz,Jakub Szlęk,Sebastian Polak,Barbara Wiśniowska,Peter Kleinebudde +6 more
TL;DR: The idea of how to combine ANNs and GP in order to escape ANNs' black-box drawback without losing their superior predictive performance was demonstrated.
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Kinetics of release of a model disperse dye from supersaturated cellulose acetate matrices.
TL;DR: General and early-time approximate expressions based on the Roseman-Higuchi model proved useful for the interpretation of the results in such cases; while the said model was extended to include the effect of significant variation of the partition coefficient of the solute with concentration.