Journal ArticleDOI
Rate of release of medicaments from ointment bases containing drugs in suspension
TLDR
An equation relating the rate of release of solid drugs suspended in ointment bases into perfect sinks is derived and the final expression is found to be surprisingly simple and convenient.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1961-10-01. It has received 2031 citations till now. The article focuses on the topics: Ointment Bases.read more
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A repeated-dose model of percutaneous drug absorption
TL;DR: In this paper, a mathematical model is developed for percutaneous absorption with regular applications of the drug, which is solved using a finite-difference method which is second-order accurate in space and time.
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Encapsulation of docetaxel in oily core polyester nanocapsules intended for breast cancer therapy
TL;DR: The data suggest that the oily core NCs are promising templates for controlled delivery of poorly water soluble chemotherapeutic agents, such as Doc.
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Mechanism of Drug Release from an Acrylic Polymer‐Wax Matrix Tablet
TL;DR: An acrylic polymer-wax matrix system was evaluated for oral sustained-release tablets of diphenhydramine HCl by incorporating Eudragit L in a carnauba wax matrix, and the drug release was described by a combination diffusion/erosion mechanism.
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Improving the release characteristics of water-soluble drugs from hydrophilic sustained release matrices by in situ gas generation
H. Hashim,A. Li Wan Po +1 more
TL;DR: In this article, a zero-order potassium chloride release from a number of compressed hydrophilic polymer tablets is investigated with a view to designing a simple zero order release system based on incorporation of low levels of effervescent mixtures within the table matrix.
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Thermosensitivity and release from poly N-isopropylacrylamide-polylactide copolymers.
TL;DR: The release profiles of the model drug indomethacin (IDM), from these thermoresponsive-co-biodegradable polymers, were found to be dependant on copolymer composition, drug loading and temperature, more rapid release occurring below the LCST.