Journal ArticleDOI
Rate of release of medicaments from ointment bases containing drugs in suspension
TLDR
An equation relating the rate of release of solid drugs suspended in ointment bases into perfect sinks is derived and the final expression is found to be surprisingly simple and convenient.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1961-10-01. It has received 2031 citations till now. The article focuses on the topics: Ointment Bases.read more
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Numerical modelling and experimental investigation of drug release from layered silicone matrix systems.
Bergthóra S. Snorradóttir,Fjola Jonsdottir,Sven Sigurdsson,Freygardur Thorsteinsson,Már Másson +4 more
TL;DR: Results indicate that numerical model can be used as a design tool for development of controlled release systems such as drug-loaded medical devices and polymeric matrix systems.
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Experimental investigation of the release mechanism of proxyphylline from silicone rubber matrices
TL;DR: The combined information derived from these techniques support the operation of a release mechanism occurring through a uniformly swollen polymer matrix without formation of cracks, in contrast to the release observed in the case of water soluble, inorganic salts where release takes place through a network of microscopic cracks.
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Permeation Study of Indomethacin from Polycarbazole/Natural Rubber Blend Film for Electric Field Controlled Transdermal Delivery
TL;DR: The influences of electric field and conductive polymer were investigated for developing a unique drug delivery system from double-centrifuged natural rubber (DCNR) matrix for transdermal drug delivery.
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Integrated Stent Models Based on Dimension Reduction: Review and Future Perspectives.
Paolo Zunino,Paolo Zunino,Josip Tambača,Elena Cutrì,Sunčica Čanić,Luca Formaggia,Francesco Migliavacca +6 more
TL;DR: This work addresses model reduction techniques for the description of stent mechanics, aiming to illustrate how a three-dimensional stent model can be transformed into a collection of interconnected one-dimensional rods, called a “stent net”, which is adopted for modeling of drug elution.
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An advanced model for composite planar three-layer matrix-controlled release devices: Part I. Devices of uniform material properties and non-uniform solute load
TL;DR: In this article, a general model capable of simulating the operation of a polymer-based, solvent-activated, symmetrical three-layer, or equivalently two-layer (AB with the B surface blocked), matrix-controlled release (MCR) device is presented and used for a parametric investigation of predicted release kinetics covering a much wider range of conditions than previously studied.