The 2016 revision of the World Health Organization classification of lymphoid neoplasms
Steven H. Swerdlow,Elias Campo,Stefano Pileri,Nancy L. Harris,Harald Stein,Reiner Siebert,Ranjana H. Advani,Michele Ghielmini,Gilles Salles,Andrew D. Zelenetz,Elaine S. Jaffe +10 more
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TLDR
The revision clarifies the diagnosis and management of lesions at the very early stages of lymphomagenesis, refines the diagnostic criteria for some entities, details the expanding genetic/molecular landscape of numerous lymphoid neoplasms and their clinical correlates, and refers to investigations leading to more targeted therapeutic strategies.About:
This article is published in Blood.The article was published on 2016-05-19 and is currently open access. It has received 5321 citations till now.read more
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Favourable outcomes for high-risk diffuse large B-cell lymphoma (IPI 3-5) treated with front-line R-CODOX-M/R-IVAC chemotherapy: results of a phase 2 UK NCRI trial.
Andrew McMillan,Elizabeth H Phillips,Amy A Kirkwood,S. Barrans,Cathy Burton,Simon Rule,Russell Patmore,Ruth Pettengell,Kirit M. Ardeshna,Anthony Lawrie,Silvia Montoto,Shankaranarayana Paneesha,Laura Clifton-Hadley,David C. Linch +13 more
TL;DR: This phase 2 trial demonstrates that R-CODOX-M/R-IVAC is a feasible and effective regimen for the treatment of younger and/or fit patients with high-risk DLBCL and warrants further investigation against standard of care.
Journal ArticleDOI
CD19-directed CAR T-cell therapy in B-cell NHL.
TL;DR: CD19-directed CAR-T-cell therapy has become standard of care for aggressive R/R diffuse large B-cell non-Hodgkin lymphoma (DLBCL), but challenges still remain.
Journal ArticleDOI
Monomorphic epitheliotropic intestinal T-cell lymphoma may mimic intestinal inflammatory disorders.
TL;DR: Being familiar with the endoscopic features and unusual histologic patterns of MEITL described here is critical for prompt diagnosis and timely treatment, which may be conductive to a better prognosis.
Journal ArticleDOI
First-line treatment in lymphomatoid papulosis: a retrospective multicentre study.
Ricardo Fernández-de-Misa,Buenaventura Hernández-Machín,Octavio Servitje,F. Valentí-Medina,Lidia Maroñas-Jiménez,Pablo L. Ortiz-Romero,J.M. Sanchez Schmidt,Ramon M. Pujol,F. Gallardo,Ignasi Pau-Charles,M P García Muret,S. Pérez Gala,Concepción Román,Javier Cañueto,L. Blanch Rius,R. Izu,Ariadna Ortiz-Brugués,Rosa M. Martí,M. Blanes,M. Morillo,Pedro de Paco Sánchez,Yeray Peñate,Jesús Bastida,A. Pérez Gil,Ingrid Lopez-Lerma,Cristina Muniesa,Teresa Estrach +26 more
TL;DR: Data regarding response to treatment in lymphomatoid papulosis (LyP) is scarce and further research is needed to establish a standard of care and establish a dose-response relationship.
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CD30 expression in extranodal natural killer/T-cell lymphoma, nasal type among 622 cases of mature T-cell and natural killer-cell lymphoma at a single institution in South China.
Yanfen Feng,Huilan Rao,Yiyan Lei,Yuhua Huang,Fang Wang,Yu Zhang,Shaoyan Xi,Qiuliang Wu,Jian Yong Shao +8 more
TL;DR: CD30 is frequently expressed in ENKTL and represents a therapeutic target; however, it may not be a prognostic marker, according to the 2016 revision of the WHO classification of lymphoid neoplasms.
References
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WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
TL;DR: Thank you very much for reading who classification of tumours of haematopoietic and lymphoid tissues, and maybe you have knowledge that, people have look hundreds of times for their chosen readings like this, but end up in malicious downloads.
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The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications.
TL;DR: The criteria and significance of early or precursor lesions and the identification of certain lymphoid neoplasms largely associated with particular age groups, such as children and the elderly are addressed, and the issue of borderline categories having overlapping features with large B-cell lymphomas is reviewed.
Journal ArticleDOI
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
Xose S. Puente,Magda Pinyol,Víctor Quesada,Laura Conde,Gonzalo R. Ordóñez,Neus Villamor,Geòrgia Escaramís,Pedro Jares,Sílvia Beà,Marcos González-Díaz,Laia Bassaganyas,Tycho Baumann,Manel Juan,Mónica López-Guerra,Dolors Colomer,Jose M. C. Tubio,Cristina López,Alba Navarro,Cristian Tornador,Marta Aymerich,María Rozman,Jesús M. Hernández,Diana A. Puente,José M.P. Freije,Gloria Velasco,Ana Gutiérrez-Fernández,Dolors Costa,Anna Carrió,Sara Guijarro,Anna Enjuanes,Lluis Hernández,Jordi Yagüe,Pilar Nicolás,Carlos M. Romeo-Casabona,Heinz Himmelbauer,Ester Castillo,Juliane C. Dohm,Silvia de Sanjosé,Miguel A. Piris,Enrique de Alava,Jesús F. San Miguel,Romina Royo,Josep Lluís Gelpí,David Torrents,Modesto Orozco,David G. Pisano,Alfonso Valencia,Roderic Guigó,Mònica Bayés,Simon Heath,Marta Gut,Peter Klatt,John Marshall,Keiran Raine,Lucy Stebbings,P. Andrew Futreal,Michael R. Stratton,Peter J. Campbell,Ivo Gut,Armando López-Guillermo,Xavier Estivill,Emili Montserrat,Carlos López-Otín,Elias Campo +63 more
TL;DR: The patterns of somatic mutation, supported by functional and clinical analyses, strongly indicate that the recurrent NOTCH1, MYD88 and XPO1 mutations are oncogenic changes that contribute to the clinical evolution of the disease.
Journal ArticleDOI
MYD88 L265P Somatic Mutation in Waldenström's Macroglobulinemia
Steven P. Treon,Lian Xu,Guang Yang,Yangsheng Zhou,Xia Liu,Yang Cao,Patricia Sheehy,Robert Manning,Christopher J. Patterson,Christina K. Tripsas,Luca Arcaini,Geraldine S. Pinkus,Scott J. Rodig,Aliyah R. Sohani,Nancy L. Harris,Jason M. Laramie,Donald A Skifter,Stephen E Lincoln,Zachary R. Hunter +18 more
TL;DR: MYD88 L265P is a commonly recurring mutation in patients with Waldenström's macroglobulinemia that can be useful in differentiating WaldenStröm’s macrogalobulinesia and non-IgM LPL from B-cell disorders that have some of the same features.
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