The 2016 revision of the World Health Organization classification of lymphoid neoplasms
Steven H. Swerdlow,Elias Campo,Stefano Pileri,Nancy L. Harris,Harald Stein,Reiner Siebert,Ranjana H. Advani,Michele Ghielmini,Gilles Salles,Andrew D. Zelenetz,Elaine S. Jaffe +10 more
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TLDR
The revision clarifies the diagnosis and management of lesions at the very early stages of lymphomagenesis, refines the diagnostic criteria for some entities, details the expanding genetic/molecular landscape of numerous lymphoid neoplasms and their clinical correlates, and refers to investigations leading to more targeted therapeutic strategies.About:
This article is published in Blood.The article was published on 2016-05-19 and is currently open access. It has received 5321 citations till now.read more
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Erdheim-Chester disease
TL;DR: Current studies have demonstrated that ECD patients bare mutations in the proto-oncogene BRAF (and more rarely in other genes involved in the MAPK activation pathway), suggesting a critical role of this pathway in the pathogenesis and a possible clonal origin of the disease.
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Long-Term Safety of Textured and Smooth Breast Implants.
M. Bradley Calobrace,M. Bradley Calobrace,Michael R Schwartz,Kamakshi R. Zeidler,Troy A. Pittman,Robert E. Cohen,W. Grant Stevens +6 more
TL;DR: This review provides a 20-year review and comparison of implant options and describes the evolution of breast implant surface textures, and explores the key benefits and risks associated with all available devices.
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Genome-wide analysis of pediatric-type follicular lymphoma reveals low genetic complexity and recurrent alterations of TNFRSF14 gene
Janine Schmidt,Shunyou Gong,Teresa Marafioti,Barbara Mankel,Blanca Gonzalez-Farre,Olga Balagué,Ana Mozos,José Cabeçadas,Jon van der Walt,Daniela Hoehn,Andreas Rosenwald,German Ott,Stefan Dojcinov,Caoimhe Egan,Ferran Nadeu,Joan Enric Ramis-Zaldivar,Guillem Clot,Carmen Bárcena,Vanesa Pérez-Alonso,Volker Endris,Roland Penzel,Carmen Lome-Maldonado,Irina Bonzheim,Falko Fend,Elias Campo,Elaine S. Jaffe,Itziar Salaverria,Leticia Quintanilla-Martinez +27 more
TL;DR: The genetic landscape of PTFL suggests that TNFRSF14 mutations accompanied by CNN-LOH of the 1p36 locus in over 70% of mutated cases, as additional selection mechanism, might play a key role in the pathogenesis of this disease.
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Characterization and risk estimate of cancer in patients with primary Sjögren syndrome
Pilar Brito-Zerón,Belchin Kostov,Guadalupe Fraile,Daniel Caravia-Durán,B. Maure,Francisco-Javier Rascón,M. Zamora,A. Casanovas,Miguel López-Dupla,M. Ripoll,Blanca Pinilla,E. Fonseca,M. Akasbi,Gloria de la Red,Miguel-Angel Duarte-Millán,P. Fanlo,Pablo Guisado-Vasco,Roberto Pérez-Alvarez,A.J. Chamorro,César Morcillo,I. Jiménez-Heredia,Isabel Sánchez-Berná,Armando López-Guillermo,Manuel Ramos-Casals +23 more
TL;DR: One third of cancers developed by patients with primary SjS are B-cell lymphomas, which is also associated with the development of some non-hematological cancers (thyroid, oral cavity, and stomach).
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The Role of Activator Protein-1 (AP-1) Family Members in CD30-Positive Lymphomas
Ines Garces de los Fayos Alonso,Ines Garces de los Fayos Alonso,Huan-Chang Liang,Suzanne D. Turner,Sabine Lagger,Olaf Merkel,Lukas Kenner,Lukas Kenner +7 more
TL;DR: The impact of deregulated expression of AP-1 TFs in CD30-positive lymphomas including Classical Hodgkin Lymphoma and Anaplastic Large Cell Lymphomas is focused on.
References
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WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
TL;DR: Thank you very much for reading who classification of tumours of haematopoietic and lymphoid tissues, and maybe you have knowledge that, people have look hundreds of times for their chosen readings like this, but end up in malicious downloads.
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The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications.
TL;DR: The criteria and significance of early or precursor lesions and the identification of certain lymphoid neoplasms largely associated with particular age groups, such as children and the elderly are addressed, and the issue of borderline categories having overlapping features with large B-cell lymphomas is reviewed.
Journal ArticleDOI
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
Xose S. Puente,Magda Pinyol,Víctor Quesada,Laura Conde,Gonzalo R. Ordóñez,Neus Villamor,Geòrgia Escaramís,Pedro Jares,Sílvia Beà,Marcos González-Díaz,Laia Bassaganyas,Tycho Baumann,Manel Juan,Mónica López-Guerra,Dolors Colomer,Jose M. C. Tubio,Cristina López,Alba Navarro,Cristian Tornador,Marta Aymerich,María Rozman,Jesús M. Hernández,Diana A. Puente,José M.P. Freije,Gloria Velasco,Ana Gutiérrez-Fernández,Dolors Costa,Anna Carrió,Sara Guijarro,Anna Enjuanes,Lluis Hernández,Jordi Yagüe,Pilar Nicolás,Carlos M. Romeo-Casabona,Heinz Himmelbauer,Ester Castillo,Juliane C. Dohm,Silvia de Sanjosé,Miguel A. Piris,Enrique de Alava,Jesús F. San Miguel,Romina Royo,Josep Lluís Gelpí,David Torrents,Modesto Orozco,David G. Pisano,Alfonso Valencia,Roderic Guigó,Mònica Bayés,Simon Heath,Marta Gut,Peter Klatt,John Marshall,Keiran Raine,Lucy Stebbings,P. Andrew Futreal,Michael R. Stratton,Peter J. Campbell,Ivo Gut,Armando López-Guillermo,Xavier Estivill,Emili Montserrat,Carlos López-Otín,Elias Campo +63 more
TL;DR: The patterns of somatic mutation, supported by functional and clinical analyses, strongly indicate that the recurrent NOTCH1, MYD88 and XPO1 mutations are oncogenic changes that contribute to the clinical evolution of the disease.
Journal ArticleDOI
MYD88 L265P Somatic Mutation in Waldenström's Macroglobulinemia
Steven P. Treon,Lian Xu,Guang Yang,Yangsheng Zhou,Xia Liu,Yang Cao,Patricia Sheehy,Robert Manning,Christopher J. Patterson,Christina K. Tripsas,Luca Arcaini,Geraldine S. Pinkus,Scott J. Rodig,Aliyah R. Sohani,Nancy L. Harris,Jason M. Laramie,Donald A Skifter,Stephen E Lincoln,Zachary R. Hunter +18 more
TL;DR: MYD88 L265P is a commonly recurring mutation in patients with Waldenström's macroglobulinemia that can be useful in differentiating WaldenStröm’s macrogalobulinesia and non-IgM LPL from B-cell disorders that have some of the same features.
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