The 2016 revision of the World Health Organization classification of lymphoid neoplasms
Steven H. Swerdlow,Elias Campo,Stefano Pileri,Nancy L. Harris,Harald Stein,Reiner Siebert,Ranjana H. Advani,Michele Ghielmini,Gilles Salles,Andrew D. Zelenetz,Elaine S. Jaffe +10 more
TLDR
The revision clarifies the diagnosis and management of lesions at the very early stages of lymphomagenesis, refines the diagnostic criteria for some entities, details the expanding genetic/molecular landscape of numerous lymphoid neoplasms and their clinical correlates, and refers to investigations leading to more targeted therapeutic strategies.About:
This article is published in Blood.The article was published on 2016-05-19 and is currently open access. It has received 5321 citations till now.read more
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A refined cell-of-origin classifier with targeted NGS and artificial intelligence shows robust predictive value in DLBCL
Zijun Y. Xu-Monette,Hongwei Zhang,Feng Zhu,Alexandar Tzankov,Govind Bhagat,Carlo Visco,Karen Dybkær,April Chiu,Wayne Tam,Youli Zu,Eric D. Hsi,Hua You,Jooryung Huh,Maurilio Ponzoni,Andrés J.M. Ferreri,Michael Boe Møller,Benjamin M. Parsons,J. Han van Krieken,Miguel A. Piris,Jane N. Winter,Fredrick B. Hagemeister,Babak Shahbaba,Ivan De Dios,Hong Zhang,Yong Li,Bing Xu,Maher Albitar,Ken H. Young,Ken H. Young +28 more
TL;DR: The results demonstrate that targeted RNA-Seq coupled with AI deep learning techniques provides reproducible, efficient, and affordable assays for clinical application and may eventually support precision medicine in DLBCL.
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Color clustering segmentation framework for image analysis of malignant lymphoid cells in peripheral blood
TL;DR: A new efficient segmentation framework has been developed, which uses the image color information through fuzzy clustering of different color components and the application of the watershed transformation with markers to distinguish among abnormal blood cells with subtile color and spatial similarities.
Journal ArticleDOI
Brentuximab vedotin for the treatment of patients with relapsed or refractory Hodgkin lymphoma after autologous stem cell transplantation
Panayotis Kaloyannidis,Mark Hertzberg,Kate Webb,Athanasios Zomas,Rudolf Schrover,Michael Hurst,I. Jacob,Thalia Nikoglou,Joseph M. Connors +8 more
TL;DR: Brentuximab vedotin (BVedotin) is the first approved novel agent for salvage treatment of relapsed or refractory (R/R) classical Hodgkin lymphoma (cHL) after autologous stem cell transplantation (ASCT) as discussed by the authors.
Journal ArticleDOI
Genomic Landscape of TCR Alpha-Beta and TCR Gamma-Delta T-Large Granular Lymphocyte Leukemia.
HeeJin Cheon,Jeffrey C. Xing,Katharine B. Moosic,Johnson Ung,Vivian Chan,David Sukwon Chung,Mariella F. Toro,Omar Elghawy,John S. Wang,Cait E. Hamele,Ross C. Hardison,Thomas L. Olson,Su-Fern Tan,David J. Feith,Ratan Aakrosh,Thomas P. Loughran +15 more
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Somatic copy number gains in MYC, BCL2, and BCL6 identifies a subset of aggressive alternative-DH/TH DLBCL patients
Jordan E. Krull,Kerstin Wenzl,Keenan T. Hartert,Michelle K. Manske,Vivekananda Sarangi,Matthew J. Maurer,Melissa C. Larson,Grzegorz S. Nowakowski,Stephen M. Ansell,Ellen D. McPhail,Thomas M. Habermann,Brian K. Link,Rebecca L. King,James R. Cerhan,Anne J. Novak +14 more
TL;DR: It is shown that concurrent translocations and copy number alterations, in combinations similar to DH/TH, identify a unique subset of DLBCL, alternative DH/ TH, that have survival outcomes similar toDH/THDLBCL patients.
References
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Book
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
TL;DR: Thank you very much for reading who classification of tumours of haematopoietic and lymphoid tissues, and maybe you have knowledge that, people have look hundreds of times for their chosen readings like this, but end up in malicious downloads.
Journal ArticleDOI
The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications.
TL;DR: The criteria and significance of early or precursor lesions and the identification of certain lymphoid neoplasms largely associated with particular age groups, such as children and the elderly are addressed, and the issue of borderline categories having overlapping features with large B-cell lymphomas is reviewed.
Journal ArticleDOI
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
Xose S. Puente,Magda Pinyol,Víctor Quesada,Laura Conde,Gonzalo R. Ordóñez,Neus Villamor,Geòrgia Escaramís,Pedro Jares,Sílvia Beà,Marcos González-Díaz,Laia Bassaganyas,Tycho Baumann,Manel Juan,Mónica López-Guerra,Dolors Colomer,Jose M. C. Tubio,Cristina López,Alba Navarro,Cristian Tornador,Marta Aymerich,María Rozman,Jesús M. Hernández,Diana A. Puente,José M.P. Freije,Gloria Velasco,Ana Gutiérrez-Fernández,Dolors Costa,Anna Carrió,Sara Guijarro,Anna Enjuanes,Lluis Hernández,Jordi Yagüe,Pilar Nicolás,Carlos M. Romeo-Casabona,Heinz Himmelbauer,Ester Castillo,Juliane C. Dohm,Silvia de Sanjosé,Miguel A. Piris,Enrique de Alava,Jesús F. San Miguel,Romina Royo,Josep Lluís Gelpí,David Torrents,Modesto Orozco,David G. Pisano,Alfonso Valencia,Roderic Guigó,Mònica Bayés,Simon Heath,Marta Gut,Peter Klatt,John Marshall,Keiran Raine,Lucy Stebbings,P. Andrew Futreal,Michael R. Stratton,Peter J. Campbell,Ivo Gut,Armando López-Guillermo,Xavier Estivill,Emili Montserrat,Carlos López-Otín,Elias Campo +63 more
TL;DR: The patterns of somatic mutation, supported by functional and clinical analyses, strongly indicate that the recurrent NOTCH1, MYD88 and XPO1 mutations are oncogenic changes that contribute to the clinical evolution of the disease.
Journal ArticleDOI
MYD88 L265P Somatic Mutation in Waldenström's Macroglobulinemia
Steven P. Treon,Lian Xu,Guang Yang,Yangsheng Zhou,Xia Liu,Yang Cao,Patricia Sheehy,Robert Manning,Christopher J. Patterson,Christina K. Tripsas,Luca Arcaini,Geraldine S. Pinkus,Scott J. Rodig,Aliyah R. Sohani,Nancy L. Harris,Jason M. Laramie,Donald A Skifter,Stephen E Lincoln,Zachary R. Hunter +18 more
TL;DR: MYD88 L265P is a commonly recurring mutation in patients with Waldenström's macroglobulinemia that can be useful in differentiating WaldenStröm’s macrogalobulinesia and non-IgM LPL from B-cell disorders that have some of the same features.
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