The 2016 revision of the World Health Organization classification of lymphoid neoplasms
Steven H. Swerdlow,Elias Campo,Stefano Pileri,Nancy L. Harris,Harald Stein,Reiner Siebert,Ranjana H. Advani,Michele Ghielmini,Gilles Salles,Andrew D. Zelenetz,Elaine S. Jaffe +10 more
TLDR
The revision clarifies the diagnosis and management of lesions at the very early stages of lymphomagenesis, refines the diagnostic criteria for some entities, details the expanding genetic/molecular landscape of numerous lymphoid neoplasms and their clinical correlates, and refers to investigations leading to more targeted therapeutic strategies.About:
This article is published in Blood.The article was published on 2016-05-19 and is currently open access. It has received 5321 citations till now.read more
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Aktualisierte S2k-Leitlinie Zöliakie der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS)
J. Felber,Hendrik Bläker,Wolfgang Fischbach,Sibylle Koletzko,Martin W. Laass,Nils Lachmann,P. Lorenz,Petra Lynen,Imke Reese,Katharina Scherf,Detlef Schuppan,Michael Schumann,Daniela Aust,S Baas,Stefan Beisel,Jan de Laffolie,E. Duba,Wolfgang Holtmeier,Ludwig Lange,Christoph Loddenkemper,Gero Moog,Timo Rath,Elke Roeb,D. Rubin,Juergen Stein,Helga-Paula Török,Yurdaguel Zopf +26 more
TL;DR: In this article , the authors present an overview of the current state of the art in the field of Histocompatibility and Immunogenetics (HCI) in the context of immunogenetics.
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MYC expression and translocation analyses in low-grade and transformed Follicular Lymphoma
Sietse M. Aukema,Sietse M. Aukema,Roel Pel,Inga Nagel,Susanne Bens,Susanne Bens,Reiner Siebert,Reiner Siebert,Stefano Rosati,Eva van den Berg,Anneke G. Bosga-Bouwer,Robby E. Kibbelaar,Mels Hoogendoorn,Gustaaf W. van Imhoff,Hanneke C. Kluin-Nelemans,Philip M. Kluin,Marcel Nijland +16 more
TL;DR: Low‐grade follicular lymphoma (FL) (grade 1/2, FL1/2) has an annual risk of transformation of 3%, which is associated with aberrations in CDKN2A/B, TP53, and MYC, which might predict a MYC breakpoint in transformed FL (tFL).
Journal ArticleDOI
The utility of flow cytometry in differentiating NK/T cell lymphoma from indolent and reactive NK cell proliferations.
Sanjay de Mel,Jenny Bei Li,Muhammad Bilal Abid,Tiffany Tang,Hui Ming Tay,Wen Chang Ting,Li Mei Poon,Tae-Hoon Chung,Benjamin Mow,Allison Ching Yee Tso,Kiat Hoe Ong,Wee Joo Chng,Te Chih Liu +12 more
TL;DR: This is the first study to compare the phenotype of NKTCL, CLPD‐NK, reactive NK lymphocytosis (RNKL), and normal NK cells using eight color (8C) FC.
Journal Article
Emerging insights on the pathogenesis and treatment of extranodal NK/T cell lymphomas (ENKTL).
Bradley M. Haverkos,Carrie B. Coleman,Alejandro A Gru,Zenggang Pan,Jonathan E. Brammer,Rosemary Rochford,Anjali Mishra,Christopher C. Oakes,Robert A. Baiocchi,Aharon G. Freud,Pierluigi Porcu +10 more
TL;DR: A number of recent discoveries including disturbances in cell signaling and mutations in tumor suppressor genes have been identified, providing insights into the pathogenesis of ENKTL, and potential therapeutic implications are discussed.
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Identifying Genetic Lesions in Ocular Adnexal Extranodal Marginal Zone Lymphomas of the MALT Subtype by Whole Genome, Whole Exome and Targeted Sequencing.
Patricia Johansson,Ludger Klein-Hitpass,Bettina Budeus,Matthias Kuhn,Chris Lauber,Michael Seifert,Ingo Roeder,R. Pförtner,Martin Stuschke,Ulrich Dührsen,Anja Eckstein,Jan Dürig,Ralf Küppers +12 more
TL;DR: Overall, this study indicated that the landscape of frequently mutated protein-coding genes in OAML is now largely known, and identified several novel genes recurrently affected by point mutations or copy number alterations.
References
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WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
TL;DR: Thank you very much for reading who classification of tumours of haematopoietic and lymphoid tissues, and maybe you have knowledge that, people have look hundreds of times for their chosen readings like this, but end up in malicious downloads.
Journal ArticleDOI
The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications.
TL;DR: The criteria and significance of early or precursor lesions and the identification of certain lymphoid neoplasms largely associated with particular age groups, such as children and the elderly are addressed, and the issue of borderline categories having overlapping features with large B-cell lymphomas is reviewed.
Journal ArticleDOI
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
Xose S. Puente,Magda Pinyol,Víctor Quesada,Laura Conde,Gonzalo R. Ordóñez,Neus Villamor,Geòrgia Escaramís,Pedro Jares,Sílvia Beà,Marcos González-Díaz,Laia Bassaganyas,Tycho Baumann,Manel Juan,Mónica López-Guerra,Dolors Colomer,Jose M. C. Tubio,Cristina López,Alba Navarro,Cristian Tornador,Marta Aymerich,María Rozman,Jesús M. Hernández,Diana A. Puente,José M.P. Freije,Gloria Velasco,Ana Gutiérrez-Fernández,Dolors Costa,Anna Carrió,Sara Guijarro,Anna Enjuanes,Lluis Hernández,Jordi Yagüe,Pilar Nicolás,Carlos M. Romeo-Casabona,Heinz Himmelbauer,Ester Castillo,Juliane C. Dohm,Silvia de Sanjosé,Miguel A. Piris,Enrique de Alava,Jesús F. San Miguel,Romina Royo,Josep Lluís Gelpí,David Torrents,Modesto Orozco,David G. Pisano,Alfonso Valencia,Roderic Guigó,Mònica Bayés,Simon Heath,Marta Gut,Peter Klatt,John Marshall,Keiran Raine,Lucy Stebbings,P. Andrew Futreal,Michael R. Stratton,Peter J. Campbell,Ivo Gut,Armando López-Guillermo,Xavier Estivill,Emili Montserrat,Carlos López-Otín,Elias Campo +63 more
TL;DR: The patterns of somatic mutation, supported by functional and clinical analyses, strongly indicate that the recurrent NOTCH1, MYD88 and XPO1 mutations are oncogenic changes that contribute to the clinical evolution of the disease.
Journal ArticleDOI
MYD88 L265P Somatic Mutation in Waldenström's Macroglobulinemia
Steven P. Treon,Lian Xu,Guang Yang,Yangsheng Zhou,Xia Liu,Yang Cao,Patricia Sheehy,Robert Manning,Christopher J. Patterson,Christina K. Tripsas,Luca Arcaini,Geraldine S. Pinkus,Scott J. Rodig,Aliyah R. Sohani,Nancy L. Harris,Jason M. Laramie,Donald A Skifter,Stephen E Lincoln,Zachary R. Hunter +18 more
TL;DR: MYD88 L265P is a commonly recurring mutation in patients with Waldenström's macroglobulinemia that can be useful in differentiating WaldenStröm’s macrogalobulinesia and non-IgM LPL from B-cell disorders that have some of the same features.
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