The 2016 revision of the World Health Organization classification of lymphoid neoplasms
Steven H. Swerdlow,Elias Campo,Stefano Pileri,Nancy L. Harris,Harald Stein,Reiner Siebert,Ranjana H. Advani,Michele Ghielmini,Gilles Salles,Andrew D. Zelenetz,Elaine S. Jaffe +10 more
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TLDR
The revision clarifies the diagnosis and management of lesions at the very early stages of lymphomagenesis, refines the diagnostic criteria for some entities, details the expanding genetic/molecular landscape of numerous lymphoid neoplasms and their clinical correlates, and refers to investigations leading to more targeted therapeutic strategies.About:
This article is published in Blood.The article was published on 2016-05-19 and is currently open access. It has received 5321 citations till now.read more
Citations
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Dual inhibition of histone deacetylases and phosphoinositide 3-kinase enhances therapeutic activity against B cell lymphoma.
Patrizia Mondello,Enrico Derenzini,Zahra Asgari,John Philip,Elliott J. Brea,Venkatraman E. Seshan,Ronald C. Hendrickson,Elisa de Stanchina,David A. Scheinberg,Anas Younes +9 more
TL;DR: Mechanistic rationale for evaluating CUDC-907 for the treatment of patients with Myc and PI3K-dependent lymphomas is provided.
Journal ArticleDOI
A four-gene LincRNA expression signature predicts risk in multiple cohorts of acute myeloid leukemia patients
Dominik Beck,Dominik Beck,Julie A. I. Thoms,Cintia Palu,Tobias Herold,Anushi Shah,Jake Olivier,Lies Boelen,Yizhou Huang,Diego Chacon,Anna L. Brown,Milena Babic,Christopher N. Hahn,Michelle Perugini,Xiaobo Zhou,Brian J. P. Huntly,Adrian Schwarzer,J-H Klusmann,Wolfgang E. Berdel,Bernhard Wörmann,Th. Büchner,Wolfgang Hiddemann,Stefan K. Bohlander,L. B. To,Hamish S. Scott,Ian D. Lewis,Ian D. Lewis,Richard J D'Andrea,Richard J D'Andrea,Jason W. H. Wong,John E. Pimanda,John E. Pimanda +31 more
TL;DR: Analysis of transcriptomic data from multiple cohorts of clinically annotated AML patients reports that microarrays designed for coding gene expression can be repurposed to yield robust lincRNA expression data and an analytical tool based on logistic regression analysis of quantitative PCR measurement of four lincRNAs can be used to determine risk in AML.
Journal ArticleDOI
Influence of oncogenic mutations and tumor microenvironment alterations on extranodal invasion in diffuse large B-cell lymphoma
Rong Shen,Pengpeng Xu,Nan Wang,Hongmei Yi,Lei Dong,Di Fu,Jinyan Huang,Hengye Huang,Anne Janin,Shu Cheng,Li Wang,Wei-Li Zhao +11 more
TL;DR: The findings of this study contribute to an improved understanding of the biological behavior of multiple ENI and provide a clinical rationale for targeting ENI in DLBCL.
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Cutaneous marginal zone lymphomas.
TL;DR: Primary cutaneous marginal zone lymphoma (CMZL) is one of the major primary B-cell lymphomas of skin, and two types are recognized: a more common class-chain switched CMZL, and a much less common IgM+ CMzL.
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Epstein-Barr virus-positive follicular lymphoma.
Nicholas Mackrides,German Campuzano-Zuluaga,Yvan Maque-Acosta,Adrienne Moul,Nouf Hijazi,Francis Offiong Ikpatt,Ronald Levy,Ramiro E. Verdun,Kranthi Kunkalla,Yasodha Natkunam,Izidore S. Lossos,Francisco Vega,Jennifer R. Chapman +12 more
TL;DR: It is suggested that EBV infection may have a role in lymphomagenesis and/or disease progression in a subset of follicular lymphomas, thereby expanding the spectrum of recognized EBV-associated B-cell lymphomas.
References
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Book
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
TL;DR: Thank you very much for reading who classification of tumours of haematopoietic and lymphoid tissues, and maybe you have knowledge that, people have look hundreds of times for their chosen readings like this, but end up in malicious downloads.
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The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications.
TL;DR: The criteria and significance of early or precursor lesions and the identification of certain lymphoid neoplasms largely associated with particular age groups, such as children and the elderly are addressed, and the issue of borderline categories having overlapping features with large B-cell lymphomas is reviewed.
Journal ArticleDOI
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
Xose S. Puente,Magda Pinyol,Víctor Quesada,Laura Conde,Gonzalo R. Ordóñez,Neus Villamor,Geòrgia Escaramís,Pedro Jares,Sílvia Beà,Marcos González-Díaz,Laia Bassaganyas,Tycho Baumann,Manel Juan,Mónica López-Guerra,Dolors Colomer,Jose M. C. Tubio,Cristina López,Alba Navarro,Cristian Tornador,Marta Aymerich,María Rozman,Jesús M. Hernández,Diana A. Puente,José M.P. Freije,Gloria Velasco,Ana Gutiérrez-Fernández,Dolors Costa,Anna Carrió,Sara Guijarro,Anna Enjuanes,Lluis Hernández,Jordi Yagüe,Pilar Nicolás,Carlos M. Romeo-Casabona,Heinz Himmelbauer,Ester Castillo,Juliane C. Dohm,Silvia de Sanjosé,Miguel A. Piris,Enrique de Alava,Jesús F. San Miguel,Romina Royo,Josep Lluís Gelpí,David Torrents,Modesto Orozco,David G. Pisano,Alfonso Valencia,Roderic Guigó,Mònica Bayés,Simon Heath,Marta Gut,Peter Klatt,John Marshall,Keiran Raine,Lucy Stebbings,P. Andrew Futreal,Michael R. Stratton,Peter J. Campbell,Ivo Gut,Armando López-Guillermo,Xavier Estivill,Emili Montserrat,Carlos López-Otín,Elias Campo +63 more
TL;DR: The patterns of somatic mutation, supported by functional and clinical analyses, strongly indicate that the recurrent NOTCH1, MYD88 and XPO1 mutations are oncogenic changes that contribute to the clinical evolution of the disease.
Journal ArticleDOI
MYD88 L265P Somatic Mutation in Waldenström's Macroglobulinemia
Steven P. Treon,Lian Xu,Guang Yang,Yangsheng Zhou,Xia Liu,Yang Cao,Patricia Sheehy,Robert Manning,Christopher J. Patterson,Christina K. Tripsas,Luca Arcaini,Geraldine S. Pinkus,Scott J. Rodig,Aliyah R. Sohani,Nancy L. Harris,Jason M. Laramie,Donald A Skifter,Stephen E Lincoln,Zachary R. Hunter +18 more
TL;DR: MYD88 L265P is a commonly recurring mutation in patients with Waldenström's macroglobulinemia that can be useful in differentiating WaldenStröm’s macrogalobulinesia and non-IgM LPL from B-cell disorders that have some of the same features.
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