The 2016 revision of the World Health Organization classification of lymphoid neoplasms
Steven H. Swerdlow,Elias Campo,Stefano Pileri,Nancy L. Harris,Harald Stein,Reiner Siebert,Ranjana H. Advani,Michele Ghielmini,Gilles Salles,Andrew D. Zelenetz,Elaine S. Jaffe +10 more
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TLDR
The revision clarifies the diagnosis and management of lesions at the very early stages of lymphomagenesis, refines the diagnostic criteria for some entities, details the expanding genetic/molecular landscape of numerous lymphoid neoplasms and their clinical correlates, and refers to investigations leading to more targeted therapeutic strategies.About:
This article is published in Blood.The article was published on 2016-05-19 and is currently open access. It has received 5321 citations till now.read more
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Angioimmunoblastic T-cell lymphoma: the many faced lymphoma
Matthew A. Lunning,Julie M. Vose +1 more
TL;DR: Induction strategies continue to focus on increasing complete remission rates that allow more transplant-eligible patients to proceed toward consolidative high-dose therapy and autologous stem cell rescue with improving long-term survival.
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Axicabtagene ciloleucel in relapsed or refractory indolent non-Hodgkin lymphoma (ZUMA-5): a single-arm, multicentre, phase 2 trial
TL;DR: In this paper , axicabtagene ciloleucel autologous anti-CD19 chimeric antigen receptor (CAR) T-cell therapy in relapsed or refractory indolent non-Hodgkin lymphoma was evaluated in the ZUMA-5 trial.
Journal ArticleDOI
Oncoplastic breast surgery--a guide to good practice.
Adam Gilmour,Ramsey I. Cutress,Ashu Gandhi,Diana Harcourt,K. Little,J. Mansell,J. Murphy,Emma Pennery,Rachel Tillett,Raghavan Vidya,Lee Martin +10 more
TL;DR: The guidelines written by an Expert Advisory Group; convened by the Association of Breast Surgery (ABS) and the British Association of Plastic, Reconstructive and Aesthetic Surgeons (BAPRAS) are designed to provide all members of the breast cancer multidisciplinary team (MDT) with guidance on the best breast surgical oncoplastic and reconstructive practice at each stage of a patient's journey, based on current evidence.
Journal ArticleDOI
Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphomas with hemophagocytic lymphohistiocytic syndrome
Tenzin Gayden,Fernando E. Sepulveda,Dong-Anh Khuong-Quang,Dong-Anh Khuong-Quang,Jonathan Pratt,Elvis Terci Valera,Elvis Terci Valera,Alexandrine Garrigue,Susan Kelso,Susan Kelso,Frank Sicheri,Frank Sicheri,Leonie G. Mikael,Nancy Hamel,Andrea Bajic,Rola Dali,Shriya Deshmukh,Dzana Dervovic,Daniel Schramek,Daniel Schramek,Frédéric Guerin,Mikko Taipale,Hamid Nikbakht,Jacek Majewski,Despina Moshous,Janie Charlebois,Sharon Abish,Christine Bole-Feysot,Patrick Nitschke,Brigitte Bader-Meunier,David Mitchell,Catherine Thieblemont,Maxime Battistella,Simon Gravel,Van-Hung Nguyen,Rachel Conyers,Rachel Conyers,Jean-Sebastien Diana,Christopher McCormack,Christopher McCormack,H. Miles Prince,Marianne Besnard,Stéphane Blanche,Paul G Ekert,Paul G Ekert,Sylvie Fraitag,William D. Foulkes,Alain Fischer,Alain Fischer,Alain Fischer,Bénédicte Neven,Bénédicte Neven,David Michonneau,Geneviève de Saint Basile,Geneviève de Saint Basile,Nada Jabado,Nada Jabado +56 more
TL;DR: G germline loss-of-function mutations in HAVCR2, which encodes the immune modulator TIM-3, are found in individuals with subcutaneous panniculitis-like T cell lymphomas and hemophagocytic lymphohistiocytosis, a life-threatening inflammatory condition.
Journal ArticleDOI
Genomic and epigenomic insights into the origin, pathogenesis, and clinical behavior of mantle cell lymphoma subtypes
Ferran Nadeu,David Martín-García,Guillem Clot,Ander Diaz-Navarro,Martí Duran-Ferrer,Alba Navarro,Roser Vilarrasa-Blasi,Marta Kulis,Romina Royo,Jesús Gutiérrez-Abril,Rafael Valdés-Mas,Cristina López,Cristina López,Vicente Chapaprieta,Montserrat Puiggròs,Giancarlo Castellano,Dolors Costa,Marta Aymerich,Pedro Jares,Blanca Espinet,Ana Muntañola,Inmaculada Ribera-Cortada,Reiner Siebert,Dolors Colomer,David Torrents,Eva Giné,Armando López-Guillermo,Ralf Küppers,José I. Martín-Subero,Xose S. Puente,Sílvia Beà,Elias Campo +31 more
TL;DR: It is identified that open and active chromatin at the major translocation cluster locus might facilitate the t(11;14)(q13;32), which modifies the 3-dimensional structure of the involved regions, and complex structural alterations emerge as a relevant early oncogenic mechanism in MCL targeting key driver genes.
References
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Book
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
TL;DR: Thank you very much for reading who classification of tumours of haematopoietic and lymphoid tissues, and maybe you have knowledge that, people have look hundreds of times for their chosen readings like this, but end up in malicious downloads.
Journal ArticleDOI
The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications.
TL;DR: The criteria and significance of early or precursor lesions and the identification of certain lymphoid neoplasms largely associated with particular age groups, such as children and the elderly are addressed, and the issue of borderline categories having overlapping features with large B-cell lymphomas is reviewed.
Journal ArticleDOI
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
Xose S. Puente,Magda Pinyol,Víctor Quesada,Laura Conde,Gonzalo R. Ordóñez,Neus Villamor,Geòrgia Escaramís,Pedro Jares,Sílvia Beà,Marcos González-Díaz,Laia Bassaganyas,Tycho Baumann,Manel Juan,Mónica López-Guerra,Dolors Colomer,Jose M. C. Tubio,Cristina López,Alba Navarro,Cristian Tornador,Marta Aymerich,María Rozman,Jesús M. Hernández,Diana A. Puente,José M.P. Freije,Gloria Velasco,Ana Gutiérrez-Fernández,Dolors Costa,Anna Carrió,Sara Guijarro,Anna Enjuanes,Lluis Hernández,Jordi Yagüe,Pilar Nicolás,Carlos M. Romeo-Casabona,Heinz Himmelbauer,Ester Castillo,Juliane C. Dohm,Silvia de Sanjosé,Miguel A. Piris,Enrique de Alava,Jesús F. San Miguel,Romina Royo,Josep Lluís Gelpí,David Torrents,Modesto Orozco,David G. Pisano,Alfonso Valencia,Roderic Guigó,Mònica Bayés,Simon Heath,Marta Gut,Peter Klatt,John Marshall,Keiran Raine,Lucy Stebbings,P. Andrew Futreal,Michael R. Stratton,Peter J. Campbell,Ivo Gut,Armando López-Guillermo,Xavier Estivill,Emili Montserrat,Carlos López-Otín,Elias Campo +63 more
TL;DR: The patterns of somatic mutation, supported by functional and clinical analyses, strongly indicate that the recurrent NOTCH1, MYD88 and XPO1 mutations are oncogenic changes that contribute to the clinical evolution of the disease.
Journal ArticleDOI
MYD88 L265P Somatic Mutation in Waldenström's Macroglobulinemia
Steven P. Treon,Lian Xu,Guang Yang,Yangsheng Zhou,Xia Liu,Yang Cao,Patricia Sheehy,Robert Manning,Christopher J. Patterson,Christina K. Tripsas,Luca Arcaini,Geraldine S. Pinkus,Scott J. Rodig,Aliyah R. Sohani,Nancy L. Harris,Jason M. Laramie,Donald A Skifter,Stephen E Lincoln,Zachary R. Hunter +18 more
TL;DR: MYD88 L265P is a commonly recurring mutation in patients with Waldenström's macroglobulinemia that can be useful in differentiating WaldenStröm’s macrogalobulinesia and non-IgM LPL from B-cell disorders that have some of the same features.
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