The 2016 revision of the World Health Organization classification of lymphoid neoplasms
Steven H. Swerdlow,Elias Campo,Stefano Pileri,Nancy L. Harris,Harald Stein,Reiner Siebert,Ranjana H. Advani,Michele Ghielmini,Gilles Salles,Andrew D. Zelenetz,Elaine S. Jaffe +10 more
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TLDR
The revision clarifies the diagnosis and management of lesions at the very early stages of lymphomagenesis, refines the diagnostic criteria for some entities, details the expanding genetic/molecular landscape of numerous lymphoid neoplasms and their clinical correlates, and refers to investigations leading to more targeted therapeutic strategies.About:
This article is published in Blood.The article was published on 2016-05-19 and is currently open access. It has received 5321 citations till now.read more
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Nivolumab in the Treatment of Hodgkin Lymphoma
TL;DR: Clinical trials are now in progress to test the use of nivolumab in combination with standard chemotherapy or with novel agents with a goal of improving the outcome of patients with Hodgkin lymphoma.
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Characteristics and Treatment of Advanced Breast Implant-Associated Anaplastic Large Cell Lymphoma
Meredith S. Collins,Roberto N. Miranda,L. Jeffrey Medeiros,Marcelo Pinheiro Silva de Meneses,Swaminathan Padmanabhan Iyer,Charles E. Butler,Jun Liu,Mark W. Clemens +7 more
TL;DR: Optimal adjuvant chemotherapy and indications for radiation for BIA-ALCL patients with advanced features are not yet clearly defined, and advanced disease is the end of the spectrum of cancer stages.
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Burkitt lymphoma in the modern era: real-world outcomes and prognostication across 30 US cancer centers
Andrew M. Evens,Alexey V. Danilov,Deepa Jagadeesh,Amy Sperling,Seo-Hyun Kim,Ryan Vaca,Catherine Wei,Daniel Rector,Suchitra Sundaram,Nishitha Reddy,Yong Lin,Umar Farooq,Christopher D'Angelo,David A. Bond,Stephanie Berg,Michael C. Churnetski,Amandeep Godara,Nadia Khan,Yun Kyong Choi,Maryam Sarraf Yazdy,Emma Rabinovich,Gaurav Varma,Reem Karmali,Agrima Mian,Malvi Savani,Madelyn Burkart,Peter Martin,Albert Ren,Ayushi Chauhan,Catherine Diefenbach,Allandria Straker-Edwards,Andreas K. Klein,Kristie A. Blum,Kirsten M Boughan,Scott E. Smith,Brad M. Haverkos,Victor M. Orellana-Noia,Vaishalee P. Kenkre,Adam Zayac,Jeremy Ramdial,Seth M. Maliske,Narendranath Epperla,Parameswaran Venugopal,Tatyana Feldman,Stephen D. Smith,Andrzej Stadnik,Kevin A. David,Seema Naik,Izidore S. Lossos,Matthew A. Lunning,Paolo Caimi,Manali Kamdar,Neil Palmisiano,Veronika Bachanova,Craig A. Portell,Tycel Phillips,Adam J. Olszewski,Juan Pablo Alderuccio +57 more
TL;DR: Outcomes for adult BL in this real-world analysis appeared more modest compared with results of clinical trials and smaller series and prognostic factors at diagnosis identified patients with divergent survival rates.
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Blastoid and pleomorphic mantle cell lymphoma: still a diagnostic and therapeutic challenge!
TL;DR: High-dose cytarabine-containing regimens with high-dose consolidation may be generally recommended based on the more aggressive clinical course in these patients, because the long-term outcome seems to be impaired.
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Cutaneous T-cell Lymphoma.
TL;DR: Basic clinical, histologic, and immunohistochemical characteristics of cutaneous T-cell lymphomas are addressed, with additional attention to evolving literature on dermoscopy, reflectance confocal microscopy, flow cytometry, and molecular data that may increasingly be applied to diagnostic and therapeutic algorithms in these diseases.
References
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Book
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
TL;DR: Thank you very much for reading who classification of tumours of haematopoietic and lymphoid tissues, and maybe you have knowledge that, people have look hundreds of times for their chosen readings like this, but end up in malicious downloads.
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The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications.
TL;DR: The criteria and significance of early or precursor lesions and the identification of certain lymphoid neoplasms largely associated with particular age groups, such as children and the elderly are addressed, and the issue of borderline categories having overlapping features with large B-cell lymphomas is reviewed.
Journal ArticleDOI
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
Xose S. Puente,Magda Pinyol,Víctor Quesada,Laura Conde,Gonzalo R. Ordóñez,Neus Villamor,Geòrgia Escaramís,Pedro Jares,Sílvia Beà,Marcos González-Díaz,Laia Bassaganyas,Tycho Baumann,Manel Juan,Mónica López-Guerra,Dolors Colomer,Jose M. C. Tubio,Cristina López,Alba Navarro,Cristian Tornador,Marta Aymerich,María Rozman,Jesús M. Hernández,Diana A. Puente,José M.P. Freije,Gloria Velasco,Ana Gutiérrez-Fernández,Dolors Costa,Anna Carrió,Sara Guijarro,Anna Enjuanes,Lluis Hernández,Jordi Yagüe,Pilar Nicolás,Carlos M. Romeo-Casabona,Heinz Himmelbauer,Ester Castillo,Juliane C. Dohm,Silvia de Sanjosé,Miguel A. Piris,Enrique de Alava,Jesús F. San Miguel,Romina Royo,Josep Lluís Gelpí,David Torrents,Modesto Orozco,David G. Pisano,Alfonso Valencia,Roderic Guigó,Mònica Bayés,Simon Heath,Marta Gut,Peter Klatt,John Marshall,Keiran Raine,Lucy Stebbings,P. Andrew Futreal,Michael R. Stratton,Peter J. Campbell,Ivo Gut,Armando López-Guillermo,Xavier Estivill,Emili Montserrat,Carlos López-Otín,Elias Campo +63 more
TL;DR: The patterns of somatic mutation, supported by functional and clinical analyses, strongly indicate that the recurrent NOTCH1, MYD88 and XPO1 mutations are oncogenic changes that contribute to the clinical evolution of the disease.
Journal ArticleDOI
MYD88 L265P Somatic Mutation in Waldenström's Macroglobulinemia
Steven P. Treon,Lian Xu,Guang Yang,Yangsheng Zhou,Xia Liu,Yang Cao,Patricia Sheehy,Robert Manning,Christopher J. Patterson,Christina K. Tripsas,Luca Arcaini,Geraldine S. Pinkus,Scott J. Rodig,Aliyah R. Sohani,Nancy L. Harris,Jason M. Laramie,Donald A Skifter,Stephen E Lincoln,Zachary R. Hunter +18 more
TL;DR: MYD88 L265P is a commonly recurring mutation in patients with Waldenström's macroglobulinemia that can be useful in differentiating WaldenStröm’s macrogalobulinesia and non-IgM LPL from B-cell disorders that have some of the same features.
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