The 2016 revision of the World Health Organization classification of lymphoid neoplasms
Steven H. Swerdlow,Elias Campo,Stefano Pileri,Nancy L. Harris,Harald Stein,Reiner Siebert,Ranjana H. Advani,Michele Ghielmini,Gilles Salles,Andrew D. Zelenetz,Elaine S. Jaffe +10 more
TLDR
The revision clarifies the diagnosis and management of lesions at the very early stages of lymphomagenesis, refines the diagnostic criteria for some entities, details the expanding genetic/molecular landscape of numerous lymphoid neoplasms and their clinical correlates, and refers to investigations leading to more targeted therapeutic strategies.About:
This article is published in Blood.The article was published on 2016-05-19 and is currently open access. It has received 5321 citations till now.read more
Citations
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Aggressive B-cell lymphomas in patients with myelofibrosis receiving JAK1/2 inhibitor therapy.
Edit Porpaczy,Sabrina Tripolt,Andrea Hoelbl-Kovacic,Bettina Gisslinger,Zsuzsanna Bago-Horvath,Zsuzsanna Bago-Horvath,Emilio Casanova-Hevia,Emmanuelle Clappier,Emmanuelle Clappier,Thomas Decker,Sabine Fajmann,Daniela A. Fux,Georg Greiner,Sinan Gueltekin,Gerwin Heller,Harald Herkner,Gregor Hoermann,Jean-Jacques Kiladjian,Thomas Kolbe,Thomas Kolbe,Christoph Kornauth,Maria-Theresa Krauth,Robert Kralovics,Leonhard Muellauer,Mathias Mueller,Michaela Prchal-Murphy,Eva Maria Putz,Emmanuel Raffoux,Ana-Iris Schiefer,Klaus G. Schmetterer,Christine Schneckenleithner,Ingrid Simonitsch-Klupp,Cathrin Skrabs,Wolfgang R. Sperr,Philipp B. Staber,Birgit Strobl,Peter Valent,Ulrich Jaeger,Heinz Gisslinger,Veronika Sexl +39 more
TL;DR: It is concluded that JAK/STAT1 pathway inhibition in myelofibrosis is associated with an elevated frequency of aggressive B-cell lymphomas and may identify individuals at risk of lymphoma development.
Journal ArticleDOI
The Role of c-MYC in B-Cell Lymphomas: Diagnostic and Molecular Aspects
TL;DR: The role that c-MYC plays in the pathogenesis of B-cell lymphomas, the molecular alterations that lead to c- MYC dysregulation, and their effect on prognosis and diagnosis are discussed.
Journal ArticleDOI
Viral Oncology: Molecular Biology and Pathogenesis.
TL;DR: In this review, the molecular biology and oncogenic pathways of established human oncoviruses will be discussed and available and emerging therapies for them will be mentioned.
Journal ArticleDOI
Cytogenetic complexity in chronic lymphocytic leukemia: definitions, associations, and clinical impact
Panagiotis Baliakas,Sabine Jeromin,Michalis Iskas,Anna Puiggros,Karla Plevová,Karla Plevová,Florence Nguyen-Khac,Zadie Davis,Gian Matteo Rigolin,Andrea Visentin,Aliki Xochelli,Julio Delgado,Fanny Baran-Marszak,Evangelia Stalika,Pau Abrisqueta,Kristina Durechova,George Papaioannou,Virginie Eclache,Maria Dimou,Theodoros Iliakis,Rosa Collado,Michael Doubek,Michael Doubek,M. Jose Calasanz,Neus Ruiz-Xivillé,Carolina Moreno,Marie Jarošová,Marie Jarošová,Alexander C. Leeksma,Panayiotis Panayiotidis,Helena Podgornik,Florence Cymbalista,Achilles Anagnostopoulos,Livio Trentin,Niki Stavroyianni,Fred Davi,Paolo Ghia,Arnon P. Kater,Antonio Cuneo,Šárka Pospíšilová,Šárka Pospíšilová,Blanca Espinet,Anastasia Athanasiadou,David Oscier,Claudia Haferlach,Kostas Stamatopoulos +45 more
TL;DR: A novel hierarchical model is proposed in which patients with high-CK exhibit the worst prognosis, whereas those with mutated CLL lacking CK or TP53abs, as well as CK with +12,+19, show the longest overall survival.
Journal ArticleDOI
Enteropathy-associated T cell lymphoma subtypes are characterized by loss of function of SETD2
Andrea B. Moffitt,Sarah L. Ondrejka,Matthew McKinney,Rachel E. Rempel,John R. Goodlad,Chun Huat Teh,Sirpa Leppä,Susanna Mannisto,Panu E. Kovanen,Eric Tse,Rex Au-Yeung,Yok-Lam Kwong,Gopesh Srivastava,Javeed Iqbal,Jiayu Yu,Kikkeri N. Naresh,Diego Villa,Randy D. Gascoyne,Jonathan W. Said,Magdalena Czader,Amy Chadburn,Kristy L. Richards,Deepthi Rajagopalan,Nicholas S. Davis,Eileen Smith,Brooke C. Palus,Tiffany Tzeng,Jane Healy,Patricia L. Lugar,Jyotishka Datta,Cassandra Love,Shawn Levy,David B. Dunson,Yuan Zhuang,Eric D. Hsi,Sandeep S. Dave +35 more
TL;DR: In this paper, the authors defined the genetic landscape of EATL through whole-exome sequencing of 69 tumors and identified mutations in KRAS, TP53, and TERT.
References
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Book
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
TL;DR: Thank you very much for reading who classification of tumours of haematopoietic and lymphoid tissues, and maybe you have knowledge that, people have look hundreds of times for their chosen readings like this, but end up in malicious downloads.
Journal ArticleDOI
The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications.
TL;DR: The criteria and significance of early or precursor lesions and the identification of certain lymphoid neoplasms largely associated with particular age groups, such as children and the elderly are addressed, and the issue of borderline categories having overlapping features with large B-cell lymphomas is reviewed.
Journal ArticleDOI
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
Xose S. Puente,Magda Pinyol,Víctor Quesada,Laura Conde,Gonzalo R. Ordóñez,Neus Villamor,Geòrgia Escaramís,Pedro Jares,Sílvia Beà,Marcos González-Díaz,Laia Bassaganyas,Tycho Baumann,Manel Juan,Mónica López-Guerra,Dolors Colomer,Jose M. C. Tubio,Cristina López,Alba Navarro,Cristian Tornador,Marta Aymerich,María Rozman,Jesús M. Hernández,Diana A. Puente,José M.P. Freije,Gloria Velasco,Ana Gutiérrez-Fernández,Dolors Costa,Anna Carrió,Sara Guijarro,Anna Enjuanes,Lluis Hernández,Jordi Yagüe,Pilar Nicolás,Carlos M. Romeo-Casabona,Heinz Himmelbauer,Ester Castillo,Juliane C. Dohm,Silvia de Sanjosé,Miguel A. Piris,Enrique de Alava,Jesús F. San Miguel,Romina Royo,Josep Lluís Gelpí,David Torrents,Modesto Orozco,David G. Pisano,Alfonso Valencia,Roderic Guigó,Mònica Bayés,Simon Heath,Marta Gut,Peter Klatt,John Marshall,Keiran Raine,Lucy Stebbings,P. Andrew Futreal,Michael R. Stratton,Peter J. Campbell,Ivo Gut,Armando López-Guillermo,Xavier Estivill,Emili Montserrat,Carlos López-Otín,Elias Campo +63 more
TL;DR: The patterns of somatic mutation, supported by functional and clinical analyses, strongly indicate that the recurrent NOTCH1, MYD88 and XPO1 mutations are oncogenic changes that contribute to the clinical evolution of the disease.
Journal ArticleDOI
MYD88 L265P Somatic Mutation in Waldenström's Macroglobulinemia
Steven P. Treon,Lian Xu,Guang Yang,Yangsheng Zhou,Xia Liu,Yang Cao,Patricia Sheehy,Robert Manning,Christopher J. Patterson,Christina K. Tripsas,Luca Arcaini,Geraldine S. Pinkus,Scott J. Rodig,Aliyah R. Sohani,Nancy L. Harris,Jason M. Laramie,Donald A Skifter,Stephen E Lincoln,Zachary R. Hunter +18 more
TL;DR: MYD88 L265P is a commonly recurring mutation in patients with Waldenström's macroglobulinemia that can be useful in differentiating WaldenStröm’s macrogalobulinesia and non-IgM LPL from B-cell disorders that have some of the same features.
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