The 2016 revision of the World Health Organization classification of lymphoid neoplasms
Steven H. Swerdlow,Elias Campo,Stefano Pileri,Nancy L. Harris,Harald Stein,Reiner Siebert,Ranjana H. Advani,Michele Ghielmini,Gilles Salles,Andrew D. Zelenetz,Elaine S. Jaffe +10 more
TLDR
The revision clarifies the diagnosis and management of lesions at the very early stages of lymphomagenesis, refines the diagnostic criteria for some entities, details the expanding genetic/molecular landscape of numerous lymphoid neoplasms and their clinical correlates, and refers to investigations leading to more targeted therapeutic strategies.About:
This article is published in Blood.The article was published on 2016-05-19 and is currently open access. It has received 5321 citations till now.read more
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Aggressive T-cell lymphomas: 2019 updates on diagnosis, risk stratification, and management
TL;DR: There are over 27 different subtypes of peripheral T‐cell lymphoma (PTCL) and the authors are now beginning to understand the differences between the various subtypes beyond histologic variations.
Journal ArticleDOI
NKp46 is a diagnostic biomarker and may be a therapeutic target in gastrointestinal T-cell lymphoproliferative diseases: A CELAC study
Morgane Cheminant,Morgane Cheminant,Morgane Cheminant,Julie Bruneau,Julie Bruneau,Julie Bruneau,Georgia Malamut,Georgia Malamut,David Sibon,David Sibon,David Sibon,Nicolas Guegan,Tom van Gils,Sascha Cording,Amélie Trinquand,Amélie Trinquand,Virginie Verkarre,Virginie Verkarre,Ludovic Lhermitte,Ludovic Lhermitte,Nicole Brousse,Nicole Brousse,Anne-Sophie Jannot,Sherine Khater,Laurent Frenzel,Laurent Frenzel,Laurent Frenzel,Richard Delarue,Richard Delarue,Felipe Suarez,Felipe Suarez,Felipe Suarez,Ambroise Marçais,Ambroise Marçais,Chris J. J. Mulder,Elizabeth Macintyre,Elizabeth Macintyre,Vahid Asnafi,Vahid Asnafi,Laurent Pouyet,C. cile Bonnafous,Florence Lhospice,Thierry Jo Molina,Thierry Jo Molina,Bertrand Meresse,Bertrand Meresse,Christophe Cellier,Christophe Cellier,Nadine Cerf-Bensussan,Nadine Cerf-Bensussan,Olivier Hermine,Olivier Hermine,Olivier Hermine +52 more
TL;DR: Strong preclinical rationale identifies anti-NKp46-PBD as a promising therapy for RCDII, EATL and MEITL.
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Two mouse models reveal an actionable PARP1 dependence in aggressive chronic lymphocytic leukemia.
Gero Knittel,Tim Rehkämper,Darya Korovkina,Paul Liedgens,Christian Fritz,Alessandro Torgovnick,Yussor Al-Baldawi,Mona Al-Maarri,Yupeng Cun,Oleg Fedorchenko,Arina Riabinska,Filippo Beleggia,Phuong-Hien Nguyen,F. Thomas Wunderlich,Monika Ortmann,Manuel Montesinos-Rongen,Eugen Tausch,Stephan Stilgenbauer,Lukas P. Frenzel,Marco Herling,Carmen D. Herling,Jasmin Bahlo,Michael Hallek,Martin Peifer,Reinhard Buettner,Thorsten Persigehl,H. Christian Reinhardt +26 more
TL;DR: Two aggressive CLL models are generated and the authors provide a preclinical rational for the use of PARP inhibitors in ATM-affected human CLL and show that Atm-deficient CLL is sensitive to PARP1 inhibition.
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Observational study of lenalidomide in patients with mantle cell lymphoma who relapsed/progressed after or were refractory/intolerant to ibrutinib (MCL-004)
Michael Wang,Stephen J. Schuster,Tycel Phillips,Izidore S. Lossos,Andre Goy,Simon Rule,Mehdi Hamadani,Nilanjan Ghosh,Craig B. Reeder,Evelyn Barnett,Marie Laure Casadebaig Bravo,Peter Martin +11 more
TL;DR: Lenalidomide-based treatment showed clinical activity, with no unexpected toxicities, in patients with relapsed/refractory mantle cell lymphoma who previously failed ibrutinib therapy.
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Mutations in the RAS-BRAF-MAPK-ERK pathway define a specific subgroup of patients with adverse clinical features and provide new therapeutic options in chronic lymphocytic leukemia.
Neus Giménez,Alejandra Martínez-Trillos,Arnau Montraveta,Mónica López-Guerra,Laia Rosich,Ferran Nadeu,Juan G. Valero,Marta Aymerich,Laura Magnano,María Rozman,Estella Matutes,Julio Delgado,Tycho Baumann,Eva Giné,Marcos González,Miguel Alcoceba,M. José Terol,Blanca Navarro,Enrique Colado,Angel Ramirez Payer,Xose S. Puente,Carlos López-Otín,Armando López-Guillermo,Elias Campo,Dolors Colomer,Neus Villamor +25 more
TL;DR: The results suggest that the RAS-BRAF-MAPK-ERK pathway is one of the core cellular processes affected by novel mutations in chronic lymphocytic leukemia, is associated with adverse clinical features and could be pharmacologically inhibited.
References
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Book
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
TL;DR: Thank you very much for reading who classification of tumours of haematopoietic and lymphoid tissues, and maybe you have knowledge that, people have look hundreds of times for their chosen readings like this, but end up in malicious downloads.
Journal ArticleDOI
The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications.
TL;DR: The criteria and significance of early or precursor lesions and the identification of certain lymphoid neoplasms largely associated with particular age groups, such as children and the elderly are addressed, and the issue of borderline categories having overlapping features with large B-cell lymphomas is reviewed.
Journal ArticleDOI
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
Xose S. Puente,Magda Pinyol,Víctor Quesada,Laura Conde,Gonzalo R. Ordóñez,Neus Villamor,Geòrgia Escaramís,Pedro Jares,Sílvia Beà,Marcos González-Díaz,Laia Bassaganyas,Tycho Baumann,Manel Juan,Mónica López-Guerra,Dolors Colomer,Jose M. C. Tubio,Cristina López,Alba Navarro,Cristian Tornador,Marta Aymerich,María Rozman,Jesús M. Hernández,Diana A. Puente,José M.P. Freije,Gloria Velasco,Ana Gutiérrez-Fernández,Dolors Costa,Anna Carrió,Sara Guijarro,Anna Enjuanes,Lluis Hernández,Jordi Yagüe,Pilar Nicolás,Carlos M. Romeo-Casabona,Heinz Himmelbauer,Ester Castillo,Juliane C. Dohm,Silvia de Sanjosé,Miguel A. Piris,Enrique de Alava,Jesús F. San Miguel,Romina Royo,Josep Lluís Gelpí,David Torrents,Modesto Orozco,David G. Pisano,Alfonso Valencia,Roderic Guigó,Mònica Bayés,Simon Heath,Marta Gut,Peter Klatt,John Marshall,Keiran Raine,Lucy Stebbings,P. Andrew Futreal,Michael R. Stratton,Peter J. Campbell,Ivo Gut,Armando López-Guillermo,Xavier Estivill,Emili Montserrat,Carlos López-Otín,Elias Campo +63 more
TL;DR: The patterns of somatic mutation, supported by functional and clinical analyses, strongly indicate that the recurrent NOTCH1, MYD88 and XPO1 mutations are oncogenic changes that contribute to the clinical evolution of the disease.
Journal ArticleDOI
MYD88 L265P Somatic Mutation in Waldenström's Macroglobulinemia
Steven P. Treon,Lian Xu,Guang Yang,Yangsheng Zhou,Xia Liu,Yang Cao,Patricia Sheehy,Robert Manning,Christopher J. Patterson,Christina K. Tripsas,Luca Arcaini,Geraldine S. Pinkus,Scott J. Rodig,Aliyah R. Sohani,Nancy L. Harris,Jason M. Laramie,Donald A Skifter,Stephen E Lincoln,Zachary R. Hunter +18 more
TL;DR: MYD88 L265P is a commonly recurring mutation in patients with Waldenström's macroglobulinemia that can be useful in differentiating WaldenStröm’s macrogalobulinesia and non-IgM LPL from B-cell disorders that have some of the same features.
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