The 2016 revision of the World Health Organization classification of lymphoid neoplasms
Steven H. Swerdlow,Elias Campo,Stefano Pileri,Nancy L. Harris,Harald Stein,Reiner Siebert,Ranjana H. Advani,Michele Ghielmini,Gilles Salles,Andrew D. Zelenetz,Elaine S. Jaffe +10 more
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TLDR
The revision clarifies the diagnosis and management of lesions at the very early stages of lymphomagenesis, refines the diagnostic criteria for some entities, details the expanding genetic/molecular landscape of numerous lymphoid neoplasms and their clinical correlates, and refers to investigations leading to more targeted therapeutic strategies.About:
This article is published in Blood.The article was published on 2016-05-19 and is currently open access. It has received 5321 citations till now.read more
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The tumour microenvironment is immuno-tolerogenic and a principal determinant of patient outcome in EBV-positive diffuse large B-cell lymphoma.
Colm Keane,Colm Keane,Joshua W.D. Tobin,Joshua W.D. Tobin,Jay Gunawardana,Santiyagu M. Savarimuthu Francis,Grace Gifford,Grace Gifford,Sara Gabrielli,Anthony J. Gill,Anthony J. Gill,William Stevenson,William Stevenson,Dipti Talaulikar,Dipti Talaulikar,Clare Gould,Clare Gould,Sanjiv Jain,Sanjiv Jain,Simone Birch,Mark P. Hertzberg,Maher K. Gandhi,Maher K. Gandhi +22 more
TL;DR: It remains untested whether the TME influences survival in EBV‐pos DLBCL, and there are no data with new digital gene expression technologies that simultaneously interrogate the virus, B cells and the tumour microenvironment (TME).
Journal ArticleDOI
Acute Myeloid Leukemia Immunophenotyping by Flow Cytometric Analysis
Xueyan Chen,Sindhu Cherian +1 more
TL;DR: The general gating strategy, antibody panels for routine analysis, and additional markers for lineage assignment in the subclassification of AML are reviewed.
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CD200 expression in mantle cell lymphoma identifies a unique subgroup of patients with frequent IGHV mutations, absence of SOX11 expression, and an indolent clinical course
Zhihong Hu,Yi Sun,Ellen J. Schlette,Guilin Tang,Shaoying Li,Jie Xu,C. Cameron Yin,Ken H. Young,Keyur P. Patel,Roberto N. Miranda,Maitrayee Goswami,Michael Wang,Jeffrey L. Jorgensen,L. Jeffrey Medeiros,Sa A. Wang +14 more
TL;DR: This is the first study to show that CD200 expression in mantle cell lymphoma, though uncommon, identifies a subgroup of mantle cellymphoma patients with characteristic pathological features, frequent non-nodal leukemic variant, and an indolent clinical course.
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Advances in the Diagnosis and Treatment of Large Granular Lymphocytic Leukemia.
HeeJin Cheon,Karolina H. Dziewulska,Katharine B. Moosic,Kristine C. Olson,Alejandro A. Gru,David J. Feith,Thomas P. Loughran +6 more
TL;DR: This review summarizes the current standard of care of LGL leukemia, updates from clinical trials, and an improved understanding of L GL pathogenesis from both the bench and the clinic, finding exciting avenues for investigations lie ahead.
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Skin colonization by circulating neoplastic clones in cutaneous T-cell lymphoma.
Aishwarya Iyer,Dylan Hennessey,Sandra O'Keefe,Jordan Patterson,Weiwei Wang,Gane Ka-Shu Wong,Robert Gniadecki,Robert Gniadecki +7 more
TL;DR: It is proposed that circulating neoplastic T-cell clones continuously replenish the lesions of MF thus increasing their heterogeneity by a mechanism analogous to the consecutive tumor seeding.
References
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Book
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
TL;DR: Thank you very much for reading who classification of tumours of haematopoietic and lymphoid tissues, and maybe you have knowledge that, people have look hundreds of times for their chosen readings like this, but end up in malicious downloads.
Journal ArticleDOI
The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications.
TL;DR: The criteria and significance of early or precursor lesions and the identification of certain lymphoid neoplasms largely associated with particular age groups, such as children and the elderly are addressed, and the issue of borderline categories having overlapping features with large B-cell lymphomas is reviewed.
Journal ArticleDOI
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
Xose S. Puente,Magda Pinyol,Víctor Quesada,Laura Conde,Gonzalo R. Ordóñez,Neus Villamor,Geòrgia Escaramís,Pedro Jares,Sílvia Beà,Marcos González-Díaz,Laia Bassaganyas,Tycho Baumann,Manel Juan,Mónica López-Guerra,Dolors Colomer,Jose M. C. Tubio,Cristina López,Alba Navarro,Cristian Tornador,Marta Aymerich,María Rozman,Jesús M. Hernández,Diana A. Puente,José M.P. Freije,Gloria Velasco,Ana Gutiérrez-Fernández,Dolors Costa,Anna Carrió,Sara Guijarro,Anna Enjuanes,Lluis Hernández,Jordi Yagüe,Pilar Nicolás,Carlos M. Romeo-Casabona,Heinz Himmelbauer,Ester Castillo,Juliane C. Dohm,Silvia de Sanjosé,Miguel A. Piris,Enrique de Alava,Jesús F. San Miguel,Romina Royo,Josep Lluís Gelpí,David Torrents,Modesto Orozco,David G. Pisano,Alfonso Valencia,Roderic Guigó,Mònica Bayés,Simon Heath,Marta Gut,Peter Klatt,John Marshall,Keiran Raine,Lucy Stebbings,P. Andrew Futreal,Michael R. Stratton,Peter J. Campbell,Ivo Gut,Armando López-Guillermo,Xavier Estivill,Emili Montserrat,Carlos López-Otín,Elias Campo +63 more
TL;DR: The patterns of somatic mutation, supported by functional and clinical analyses, strongly indicate that the recurrent NOTCH1, MYD88 and XPO1 mutations are oncogenic changes that contribute to the clinical evolution of the disease.
Journal ArticleDOI
MYD88 L265P Somatic Mutation in Waldenström's Macroglobulinemia
Steven P. Treon,Lian Xu,Guang Yang,Yangsheng Zhou,Xia Liu,Yang Cao,Patricia Sheehy,Robert Manning,Christopher J. Patterson,Christina K. Tripsas,Luca Arcaini,Geraldine S. Pinkus,Scott J. Rodig,Aliyah R. Sohani,Nancy L. Harris,Jason M. Laramie,Donald A Skifter,Stephen E Lincoln,Zachary R. Hunter +18 more
TL;DR: MYD88 L265P is a commonly recurring mutation in patients with Waldenström's macroglobulinemia that can be useful in differentiating WaldenStröm’s macrogalobulinesia and non-IgM LPL from B-cell disorders that have some of the same features.
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