The 2016 revision of the World Health Organization classification of lymphoid neoplasms
Steven H. Swerdlow,Elias Campo,Stefano Pileri,Nancy L. Harris,Harald Stein,Reiner Siebert,Ranjana H. Advani,Michele Ghielmini,Gilles Salles,Andrew D. Zelenetz,Elaine S. Jaffe +10 more
TLDR
The revision clarifies the diagnosis and management of lesions at the very early stages of lymphomagenesis, refines the diagnostic criteria for some entities, details the expanding genetic/molecular landscape of numerous lymphoid neoplasms and their clinical correlates, and refers to investigations leading to more targeted therapeutic strategies.About:
This article is published in Blood.The article was published on 2016-05-19 and is currently open access. It has received 5321 citations till now.read more
Citations
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Environmental and Other Extrinsic Risk Factors Contributing to the Pathogenesis of Cutaneous T Cell Lymphoma (CTCL).
Feras M. Ghazawi,Nebras Alghazawi,Michelle Le,Elena Netchiporouk,Steven J. Glassman,Denis Sasseville,Ivan V. Litvinov +6 more
TL;DR: The known risk factors including sex, age, race as well as environmental, infectious, iatrogenic and other exposures, that are implicated in CTCL lymphomagenesis are reviewed and conceivable mechanisms by which these factors may trigger this malignancy are discussed.
Journal ArticleDOI
Axicabtagene ciloleucel (KTE-C19), an anti-CD19 CAR T therapy for the treatment of relapsed/refractory aggressive B-cell non-Hodgkin's lymphoma.
TL;DR: The CD19 chimeric antigen receptor T-specific toxicities of cytokine release syndrome and neurotoxicity remain the challenges to the safe delivery of this important therapy for aggressive B-cell lymphomas with poor prognosis.
Journal ArticleDOI
TMEM30A loss-of-function mutations drive lymphomagenesis and confer therapeutically exploitable vulnerability in B-cell lymphoma.
Daisuke Ennishi,Shannon Healy,Ali Bashashati,Saeed Saberi,Christoffer Hother,Anja Mottok,Fong Chun Chan,Lauren Chong,Libin Abraham,Robert Kridel,Merrill Boyle,Barbara Meissner,Tomohiro Aoki,Katsuyoshi Takata,Bruce Woolcock,Elena Viganò,Michael R. Gold,Laurie L. Molday,Robert S. Molday,Adele Telenius,Michael Y. Li,Nicole Wretham,Nancy Dos Santos,Mark Wong,Natasja N. Viller,Robert A. Uger,Gerben Duns,Abigail Baticados,Angel Madero,Brianna N. Bristow,Pedro Farinha,Graham W. Slack,Susana Ben-Neriah,Daniel Lai,Allen W. Zhang,Sohrab Salehi,Hennady P. Shulha,Derek S. Chiu,Sara Mostafavi,Alina S. Gerrie,Da Wei Huang,Christopher Rushton,Diego Villa,Laurie H. Sehn,Kerry J. Savage,Andrew J. Mungall,Andrew P. Weng,Marcel B. Bally,Ryan D. Morin,Gabriela V. Cohen Freue,Louis M. Staudt,Joseph M. Connors,Marco A. Marra,Sohrab P. Shah,Randy D. Gascoyne,David Scott,Christian Steidl +56 more
TL;DR: A multifaceted role for TMEM30A in B-cell lymphomagenesis is highlighted, and intrinsic and extrinsic vulnerabilities of cancer cells that can be therapeutically exploited are characterized.
Journal ArticleDOI
Cathepsin S Alterations Induce a Tumor-Promoting Immune Microenvironment in Follicular Lymphoma
Deepak Bararia,Deepak Bararia,Johannes A. Hildebrand,Johannes A. Hildebrand,Sebastian Stolz,Sarah Haebe,Stefan Alig,Christopher P. Trevisani,Francisco Osorio-Barrios,Michael D. Bartoschek,Michael Mentz,Alessandro Pastore,Erik Gaitzsch,Erik Gaitzsch,Michael Heide,Michael Heide,Vindi Jurinovic,Katharina Rautter,Jay Gunawardana,Muhammed B. Sabdia,Monika Szczepanowski,Julia Richter,Wolfram Klapper,Abner Louissaint,Christina Ludwig,Sebastian Bultmann,Heinrich Leonhardt,Sebastian Eustermann,Karl-Peter Hopfner,Wolfgang Hiddemann,Wolfgang Hiddemann,Michael von Bergwelt-Baildon,Michael von Bergwelt-Baildon,Christian Steidl,Robert Kridel,Joshua W.D. Tobin,Maher K. Gandhi,David M. Weinstock,Marc Schmidt-Supprian,Menyhárt B. Sárosi,Martina Rudelius,Verena Passerini,Verena Passerini,Josef Mautner,Oliver Weigert,Oliver Weigert +45 more
TL;DR: Clinically, patients with CTSS-hyperactive FL had better treatment outcomes with standard immunochemotherapies, indicating that these immunosuppressive regimens target both the lymphoma cells and the tumor-promoting immune microenvironment.
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Expression of p63 protein in anaplastic large cell lymphoma: implications for genetic subtyping
Xueju Wang,Rebecca L. Boddicker,Surendra Dasari,Jagmohan S. Sidhu,Marshall E. Kadin,William R. Macon,Stephen M. Ansell,Rhett P. Ketterling,Karen L. Rech,Andrew L. Feldman +9 more
TL;DR: It is indicated that ALCLs without TP63 rearrangements may express TAp63 isoforms of p63 and that this expression is associated with extra copies of TP63, probably due to widespread genomic copy number abnormalities rather than focal gains.
References
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Book
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
TL;DR: Thank you very much for reading who classification of tumours of haematopoietic and lymphoid tissues, and maybe you have knowledge that, people have look hundreds of times for their chosen readings like this, but end up in malicious downloads.
Journal ArticleDOI
The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications.
TL;DR: The criteria and significance of early or precursor lesions and the identification of certain lymphoid neoplasms largely associated with particular age groups, such as children and the elderly are addressed, and the issue of borderline categories having overlapping features with large B-cell lymphomas is reviewed.
Journal ArticleDOI
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
Xose S. Puente,Magda Pinyol,Víctor Quesada,Laura Conde,Gonzalo R. Ordóñez,Neus Villamor,Geòrgia Escaramís,Pedro Jares,Sílvia Beà,Marcos González-Díaz,Laia Bassaganyas,Tycho Baumann,Manel Juan,Mónica López-Guerra,Dolors Colomer,Jose M. C. Tubio,Cristina López,Alba Navarro,Cristian Tornador,Marta Aymerich,María Rozman,Jesús M. Hernández,Diana A. Puente,José M.P. Freije,Gloria Velasco,Ana Gutiérrez-Fernández,Dolors Costa,Anna Carrió,Sara Guijarro,Anna Enjuanes,Lluis Hernández,Jordi Yagüe,Pilar Nicolás,Carlos M. Romeo-Casabona,Heinz Himmelbauer,Ester Castillo,Juliane C. Dohm,Silvia de Sanjosé,Miguel A. Piris,Enrique de Alava,Jesús F. San Miguel,Romina Royo,Josep Lluís Gelpí,David Torrents,Modesto Orozco,David G. Pisano,Alfonso Valencia,Roderic Guigó,Mònica Bayés,Simon Heath,Marta Gut,Peter Klatt,John Marshall,Keiran Raine,Lucy Stebbings,P. Andrew Futreal,Michael R. Stratton,Peter J. Campbell,Ivo Gut,Armando López-Guillermo,Xavier Estivill,Emili Montserrat,Carlos López-Otín,Elias Campo +63 more
TL;DR: The patterns of somatic mutation, supported by functional and clinical analyses, strongly indicate that the recurrent NOTCH1, MYD88 and XPO1 mutations are oncogenic changes that contribute to the clinical evolution of the disease.
Journal ArticleDOI
MYD88 L265P Somatic Mutation in Waldenström's Macroglobulinemia
Steven P. Treon,Lian Xu,Guang Yang,Yangsheng Zhou,Xia Liu,Yang Cao,Patricia Sheehy,Robert Manning,Christopher J. Patterson,Christina K. Tripsas,Luca Arcaini,Geraldine S. Pinkus,Scott J. Rodig,Aliyah R. Sohani,Nancy L. Harris,Jason M. Laramie,Donald A Skifter,Stephen E Lincoln,Zachary R. Hunter +18 more
TL;DR: MYD88 L265P is a commonly recurring mutation in patients with Waldenström's macroglobulinemia that can be useful in differentiating WaldenStröm’s macrogalobulinesia and non-IgM LPL from B-cell disorders that have some of the same features.
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