The 2016 revision of the World Health Organization classification of lymphoid neoplasms
Steven H. Swerdlow,Elias Campo,Stefano Pileri,Nancy L. Harris,Harald Stein,Reiner Siebert,Ranjana H. Advani,Michele Ghielmini,Gilles Salles,Andrew D. Zelenetz,Elaine S. Jaffe +10 more
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TLDR
The revision clarifies the diagnosis and management of lesions at the very early stages of lymphomagenesis, refines the diagnostic criteria for some entities, details the expanding genetic/molecular landscape of numerous lymphoid neoplasms and their clinical correlates, and refers to investigations leading to more targeted therapeutic strategies.About:
This article is published in Blood.The article was published on 2016-05-19 and is currently open access. It has received 5321 citations till now.read more
Citations
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SYK expression in monomorphic epitheliotropic intestinal T-cell lymphoma.
Grit Mutzbauer,Katja Maurus,Clara Buszello,Jordan Pischimarov,Sabine Roth,Andreas Rosenwald,Andreas Chott,Eva Geissinger +7 more
TL;DR: The immunohistochemical expression of the spleen tyrosine kinase (SYK) turned out to be a distinctive feature of MEITL (95%) compared with EATL (0%).
Journal ArticleDOI
High activation of STAT5A drives peripheral T-cell lymphoma and leukemia
Barbara Maurer,Harini Nivarthi,Bettina Wingelhofer,Ha Thi Thanh Pham,Michaela Schlederer,Tobias Suske,Reinhard Grausenburger,Ana-Iris Schiefer,Michaela Prchal-Murphy,Doris Chen,Susanne Winkler,Olaf Merkel,Christoph Kornauth,Maximilian Hofbauer,Birgit Hochgatterer,Gregor Hoermann,Andrea Hoelbl-Kovacic,Jana Prochazkova,Cosimo Lobello,Abbarna A. Cumaraswamy,Johanna Latzka,Melitta Kitzwögerer,Andreas Chott,Andrea Janíková,Šárka Pospíšilová,Joanna I. Loizou,Stefan Kubicek,Peter Valent,Thomas Kolbe,Florian Grebien,Lukas Kenner,Patrick T. Gunning,Robert Kralovics,Marco Herling,Mathias Müller,Thomas Rülicke,Veronika Sexl,Richard Moriggl +37 more
TL;DR: It is concluded that enhanced STAT5A or STAT5B action both drive PTCL development, defining both STAT5 molecules as targets for therapeutic intervention.
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Circular RNAs in Blood Malignancies.
TL;DR: The usefulness of circRNAs as diagnostic and prognostic markers and their potential value as therapeutic targets are discussed.
Journal ArticleDOI
Microenvironment Cell Contribution to Lymphoma Immunity.
Deepika Kumar,Mina L. Xu +1 more
TL;DR: The roles of mesenchymal stem/stromal cells (MSCs), lymphoma-associated macrophages (LAMs), dendritic cells, cytotoxic T cells, PD-1 expressing CD4+ tumor infiltrating lymphocytes (TILs), T-cells expressing markers of exhaustion such as TIM-3 and LAG-3, regulatory T Cells, and natural killer cells are described.
Journal ArticleDOI
The Role of Immune Checkpoint Inhibitors in Classical Hodgkin Lymphoma.
TL;DR: The biology of HL is reviewed, with a focus on the immune micro-environment and mechanisms of immune evasion, and the rationale supporting the use of PD-1 inhibitors in HL is provided.
References
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Book
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
TL;DR: Thank you very much for reading who classification of tumours of haematopoietic and lymphoid tissues, and maybe you have knowledge that, people have look hundreds of times for their chosen readings like this, but end up in malicious downloads.
Journal ArticleDOI
The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications.
TL;DR: The criteria and significance of early or precursor lesions and the identification of certain lymphoid neoplasms largely associated with particular age groups, such as children and the elderly are addressed, and the issue of borderline categories having overlapping features with large B-cell lymphomas is reviewed.
Journal ArticleDOI
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
Xose S. Puente,Magda Pinyol,Víctor Quesada,Laura Conde,Gonzalo R. Ordóñez,Neus Villamor,Geòrgia Escaramís,Pedro Jares,Sílvia Beà,Marcos González-Díaz,Laia Bassaganyas,Tycho Baumann,Manel Juan,Mónica López-Guerra,Dolors Colomer,Jose M. C. Tubio,Cristina López,Alba Navarro,Cristian Tornador,Marta Aymerich,María Rozman,Jesús M. Hernández,Diana A. Puente,José M.P. Freije,Gloria Velasco,Ana Gutiérrez-Fernández,Dolors Costa,Anna Carrió,Sara Guijarro,Anna Enjuanes,Lluis Hernández,Jordi Yagüe,Pilar Nicolás,Carlos M. Romeo-Casabona,Heinz Himmelbauer,Ester Castillo,Juliane C. Dohm,Silvia de Sanjosé,Miguel A. Piris,Enrique de Alava,Jesús F. San Miguel,Romina Royo,Josep Lluís Gelpí,David Torrents,Modesto Orozco,David G. Pisano,Alfonso Valencia,Roderic Guigó,Mònica Bayés,Simon Heath,Marta Gut,Peter Klatt,John Marshall,Keiran Raine,Lucy Stebbings,P. Andrew Futreal,Michael R. Stratton,Peter J. Campbell,Ivo Gut,Armando López-Guillermo,Xavier Estivill,Emili Montserrat,Carlos López-Otín,Elias Campo +63 more
TL;DR: The patterns of somatic mutation, supported by functional and clinical analyses, strongly indicate that the recurrent NOTCH1, MYD88 and XPO1 mutations are oncogenic changes that contribute to the clinical evolution of the disease.
Journal ArticleDOI
MYD88 L265P Somatic Mutation in Waldenström's Macroglobulinemia
Steven P. Treon,Lian Xu,Guang Yang,Yangsheng Zhou,Xia Liu,Yang Cao,Patricia Sheehy,Robert Manning,Christopher J. Patterson,Christina K. Tripsas,Luca Arcaini,Geraldine S. Pinkus,Scott J. Rodig,Aliyah R. Sohani,Nancy L. Harris,Jason M. Laramie,Donald A Skifter,Stephen E Lincoln,Zachary R. Hunter +18 more
TL;DR: MYD88 L265P is a commonly recurring mutation in patients with Waldenström's macroglobulinemia that can be useful in differentiating WaldenStröm’s macrogalobulinesia and non-IgM LPL from B-cell disorders that have some of the same features.
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