The 2016 revision of the World Health Organization classification of lymphoid neoplasms
Steven H. Swerdlow,Elias Campo,Stefano Pileri,Nancy L. Harris,Harald Stein,Reiner Siebert,Ranjana H. Advani,Michele Ghielmini,Gilles Salles,Andrew D. Zelenetz,Elaine S. Jaffe +10 more
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TLDR
The revision clarifies the diagnosis and management of lesions at the very early stages of lymphomagenesis, refines the diagnostic criteria for some entities, details the expanding genetic/molecular landscape of numerous lymphoid neoplasms and their clinical correlates, and refers to investigations leading to more targeted therapeutic strategies.About:
This article is published in Blood.The article was published on 2016-05-19 and is currently open access. It has received 5321 citations till now.read more
Citations
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T-Cell Lymphoma: Recent Advances in Characterization and New Opportunities for Treatment.
Carla Casulo,Owen A. O'Connor,Andrei R. Shustov,Michelle A. Fanale,Jonathan W. Friedberg,John P. Leonard,Brad S. Kahl,Richard F. Little,Lauren C. Pinter-Brown,Ranjani Advani,Steven M. Horwitz +10 more
TL;DR: The need for the identification and development of active and biologically rational therapies to cure PTCL at higher rates is underscored, with iterative biomarker evaluation.
Journal ArticleDOI
Frequent somatic TET2 mutations in chronic NK-LGL leukemia with distinct patterns of cytopenias
Thomas L. Olson,Hee Jin Cheon,Jeffrey C. Xing,Kristine C. Olson,Umadevi Paila,Cait E. Hamele,Yaseswini Neelamraju,Bryna C. Shemo,Matt Schmachtenberg,Shriram K. Sundararaman,Mariella F. Toro,Cheryl A. Keller,Emily Farber,Suna Onengut-Gumuscu,Francine E. Garrett-Bakelman,Ross C. Hardison,David J. Feith,Aakrosh Ratan,Thomas P. Loughran +18 more
TL;DR: In this article, the authors used bisulfite sequencing to identify mutations unique to chronic lymphoproliferative disorder of large granular lymphocyte (LGL) cells, which is a rare disorder defined by prolonged expansion of clonal NK cells.
Journal ArticleDOI
Bromodomain inhibitor OTX015 (MK-8628) combined with targeted agents shows strong in vivo antitumor activity in lymphoma
Eugenio Gaudio,Chiara Tarantelli,Maurilio Ponzoni,Elodie Odore,Keyvan Rezai,Elena Bernasconi,Luciano Cascione,Andrea Rinaldi,Anastasios Stathis,Eugenia Riveiro,Esteban Cvitkovic,Emanuele Zucca,Francesco Bertoni +12 more
TL;DR: In vivo data for OTX015 in combination with the histone deacetylase inhibitor vorinostat, the Bruton's tyrosine kinase inhibitor ibrutinib, the anti-CD20 monoclonal antibody rituximab, and the mTOR inhibitor everolimus in a diffuse large B cell lymphoma model provides a strong rationale to explore OTX2015-containing combinations in the clinical lymphoma setting.
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A Clinically Applicable Approach to the Classification of B-Cell Non-Hodgkin Lymphomas with Flow Cytometry and Machine Learning.
Valentina Gaidano,Valerio Tenace,Nathalie Santoro,Silvia Varvello,Alessandro Cignetti,Giuseppina Prato,Giuseppe Saglio,Giovanni De Rosa,Massimo Geuna +8 more
TL;DR: Four artificial predictive systems are built which could classify B-NHL in up to nine of the most common clinico-pathological entities, demonstrating the strong discriminatory power of MIB1 and Bcl2 and the potential usefulness of some non-canonical markers in categorizing B-nHL.
Journal Article
Expression of exportin-1 in diffuse large B-cell lymphoma: immunohistochemistry and TCGA analyses.
Bin Luo,Lanshan Huang,Yong-Yao Gu,Chun-Yao Li,Hui-Ping Lu,Gang Chen,Zhi-Gang Peng,Zhen-Bo Feng +7 more
TL;DR: High XPO1 expression in DLBCL was related to an advanced clinical stage, poor IPI score, and poor prognosis, and may be useful for condition identification and prognostic assessment.
References
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Book
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
TL;DR: Thank you very much for reading who classification of tumours of haematopoietic and lymphoid tissues, and maybe you have knowledge that, people have look hundreds of times for their chosen readings like this, but end up in malicious downloads.
Journal ArticleDOI
The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications.
TL;DR: The criteria and significance of early or precursor lesions and the identification of certain lymphoid neoplasms largely associated with particular age groups, such as children and the elderly are addressed, and the issue of borderline categories having overlapping features with large B-cell lymphomas is reviewed.
Journal ArticleDOI
Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia
Xose S. Puente,Magda Pinyol,Víctor Quesada,Laura Conde,Gonzalo R. Ordóñez,Neus Villamor,Geòrgia Escaramís,Pedro Jares,Sílvia Beà,Marcos González-Díaz,Laia Bassaganyas,Tycho Baumann,Manel Juan,Mónica López-Guerra,Dolors Colomer,Jose M. C. Tubio,Cristina López,Alba Navarro,Cristian Tornador,Marta Aymerich,María Rozman,Jesús M. Hernández,Diana A. Puente,José M.P. Freije,Gloria Velasco,Ana Gutiérrez-Fernández,Dolors Costa,Anna Carrió,Sara Guijarro,Anna Enjuanes,Lluis Hernández,Jordi Yagüe,Pilar Nicolás,Carlos M. Romeo-Casabona,Heinz Himmelbauer,Ester Castillo,Juliane C. Dohm,Silvia de Sanjosé,Miguel A. Piris,Enrique de Alava,Jesús F. San Miguel,Romina Royo,Josep Lluís Gelpí,David Torrents,Modesto Orozco,David G. Pisano,Alfonso Valencia,Roderic Guigó,Mònica Bayés,Simon Heath,Marta Gut,Peter Klatt,John Marshall,Keiran Raine,Lucy Stebbings,P. Andrew Futreal,Michael R. Stratton,Peter J. Campbell,Ivo Gut,Armando López-Guillermo,Xavier Estivill,Emili Montserrat,Carlos López-Otín,Elias Campo +63 more
TL;DR: The patterns of somatic mutation, supported by functional and clinical analyses, strongly indicate that the recurrent NOTCH1, MYD88 and XPO1 mutations are oncogenic changes that contribute to the clinical evolution of the disease.
Journal ArticleDOI
MYD88 L265P Somatic Mutation in Waldenström's Macroglobulinemia
Steven P. Treon,Lian Xu,Guang Yang,Yangsheng Zhou,Xia Liu,Yang Cao,Patricia Sheehy,Robert Manning,Christopher J. Patterson,Christina K. Tripsas,Luca Arcaini,Geraldine S. Pinkus,Scott J. Rodig,Aliyah R. Sohani,Nancy L. Harris,Jason M. Laramie,Donald A Skifter,Stephen E Lincoln,Zachary R. Hunter +18 more
TL;DR: MYD88 L265P is a commonly recurring mutation in patients with Waldenström's macroglobulinemia that can be useful in differentiating WaldenStröm’s macrogalobulinesia and non-IgM LPL from B-cell disorders that have some of the same features.
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